Evidence map›Paper›PMID 30172098›Full record

ArticleAmerican heart journal2018

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design.

Sripal Bangalore, David J Maron, Jerome L Fleg, Sean M O'Brien, Charles A Herzog, Gregg W Stone, Daniel B Mark, John A Spertus, Karen P Alexander, Mandeep S Sidhu and 4 more

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01985360 (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Chronic Kidney Disease Trial), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
20.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01985360 phase4completednot on this map

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Chronic Kidney Disease Trial

TypeinterventionalSponsorNYU Langone HealthRan2014 to 2020Enrolled777ConditionsCardiovascular Diseases, Coronary Artery Disease, Heart Diseases, Myocardial IschemiaArmsCardiac Catheterization, Coronary Artery Bypass Graft Surgery, Percutaneous Coronary Intervention, Lifestyle, Medication
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Kidney Transplant List Status and Outcomes in the ISCHEMIA-CKD Trial.Journal of the American College of Cardiology · 2021
    Trial
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Article
  19. Article
  20. Coronary Artery Disease in CKD-G5D Patients: An Update.Reviews in cardiovascular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Sripal BangaloreNew York University School of Medicine, New York, NY. Electronic address: sripalbangalore@gmail.com.
David J MaronStanford University School of Medicine, Stanford, CA.
Jerome L FlegNational Heart Lung and Blood Institute, Bethesda, MD.
Sean M O'BrienDuke Clinical Research Institute, Durham, NC.
Charles A HerzogHennepin County Medical Center and University of Minnesota, Minneapolis, MN.
Gregg W StoneNew York Presbyterian Hospital, Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY.
Daniel B MarkDuke Clinical Research Institute, Durham, NC.
John A SpertusMid-America Heart Institute/University of Missouri-Kansas City, Kansas City, MO.
Karen P AlexanderDuke Clinical Research Institute, Durham, NC.
Mandeep S SidhuAlbany Medical Center, Albany, NY.
Glenn M ChertowStanford University School of Medicine, Stanford, CA.
William E BodenVeterans Affairs New England Healthcare System, Massachusetts Veterans Epidemiology, Research, and Informatics Center, Boston, MA.
Judith S HochmanNew York University School of Medicine, New York, NY.
ISCHEMIA-CKD Research Group
Clinical Research Institute · USNew York University · USStanford University · USAlbany Medical Center Hospital · USColumbia University Irving Medical Center · USHennepin County Medical Center · USNational Heart Lung and Blood Institute · USUniversity of Missouri–Kansas City · USVA New England Healthcare System · US

Funding

The ISCHEMIA-CKD Trial-CCC-Lead ApplicationU01HL117905 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BANGALORE, SRIPAL · 2013 to 2019
$9.8M
ISCHEMIA-CKD SDCCU01HL117904 · NHLBI · DUKE UNIVERSITY · PI O'BRIEN, SEAN M · 2013 to 2019
$1.5M
NHLBI NIH HHS U01 HL117904NHLBI NIH HHS U01 HL117905
6 · The paper itself

Abstract

backgroundPatients with chronic kidney disease (CKD) and stable ischemic heart disease are at markedly increased risk of cardiovascular events. Prior trials comparing a strategy of optimal medical therapy (OMT) with or without revascularization have largely excluded patients with advanced CKD. Whether a routine invasive approach when compared with a conservative strategy is beneficial in such patients is unknown.

methodsISCHEMIA-CKD is a National Heart, Lung, and Blood Institute-funded randomized trial designed to determine the comparative effectiveness of an initial invasive strategy (cardiac catheterization and optimal revascularization [percutaneous coronary intervention or coronary artery bypass graft surgery, if suitable] plus OMT) versus a conservative strategy (OMT alone, with cardiac catheterization and revascularization [percutaneous coronary intervention or coronary artery bypass graft surgery, if suitable] reserved for failure of OMT) on long-term clinical outcomes in 777 patients with advanced CKD (defined as those with estimated glomerular filtration rate <30 mL/min/1.73m

conclusionsISCHEMIA-CKD will determine whether an initial invasive management strategy improves clinical outcomes when added to OMT in patients with advanced CKD and stable ischemic heart disease.

Indexed as

Quality of LifeAgedCardiac CatheterizationConservative TreatmentFemaleGlomerular Filtration RateHumansMaleMiddle AgedMulticenter Studies as TopicMyocardial IschemiaMyocardial RevascularizationRandomized Controlled Trials as TopicRenal Insufficiency, ChronicTreatment Outcome

Identifiers

PMID30172098
PMCPMC6283671
OpenAlexW2887879333

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.