Evidence map›Paper›PMID 30172032›Full record

ArticleJournal of critical care2018

Donor biomarkers as predictors of organ use and recipient survival after neurologically deceased donor organ transplantation.

Shengnan Li, Shu Wang, Raghavan Murugan, Ali Al-Khafaji, Daniel J Lebovitz, Michael Souter, Susan R N Stuart, John A Kellum, Monitoring Organ Donors to Improve Transplantation Results (MOnIToR) Study Investigators

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of critical care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00987714 (Monitoring Organ Donors to Increase Transplantation Results), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00987714 nacompletednot on this map

Monitoring Organ Donors to Increase Transplantation Results

TypeinterventionalSponsorUniversity of PittsburghRan2009 to 2013Enrolled556ConditionsTransplantationArmsProtocolized care
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shengnan LiCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
Shu WangCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, United States.
Raghavan MuruganCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; The CRISMA (Clinical Research, Investigation and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Ali Al-KhafajiCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; The CRISMA (Clinical Research, Investigation and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Daniel J LebovitzDepartment of Critical Care, Akron Children's Hospital, Akron, OH, United States.
Michael SouterDepartment of Anesthesiology & Pain Medicine, University of Washington, Harborview Medical Center, Seattle, WA, United States.
Susan R N StuartCenter for Organ Recovery and Education, Pittsburgh, PA, United States.
John A KellumCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; The CRISMA (Clinical Research, Investigation and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. Electronic address: kellum@pitt.edu.
Monitoring Organ Donors to Improve Transplantation Results (MOnIToR) Study Investigators

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Protocolized Goal-directed Resuscitation of Septic Shock to Prevent AKI (ProGReSSR01DK083961 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELLUM, JOHN A · 2010 to 2013
$2.6M
NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153NIDDK NIH HHS R01 DK083961
6 · The paper itself

Abstract

purposeWe sought to build prediction models for organ transplantation and recipient survival using both biomarkers and clinical information. MATERIALS AND

methodsWe abstracted clinical variables from a previous randomized trial (n = 556) of donor management. In a subset of donors (n = 97), we measured two candidate biomarkers in plasma at enrollment and just prior to explantation.

resultsSecretory leukocyte protease inhibitor (SLPI) was significant for predicting liver transplantation (C-statistic 0.65 (0.53, 0.78)). SLPI also significantly improved the predictive performance of a clinical model for liver transplantation (integrated discrimination improvement (IDI): 0.090 (0.009, 0.210)). For other organs, clinical variables alone had strong predictive ability (C-statistic >0.80). Recipient 3-years survival was 80.0% (71.9%, 87.0%). Donor IL-6 was significantly associated with recipient 3-years survival (adjusted Hazard Ratio (95%CI): 1.26(1.08, 1.48), P = .004). Neither clinical variables nor biomarkers showed strong predictive ability for 3-year recipient survival.

conclusionsPlasma biomarkers in neurologically deceased donors were associated with organ use. SLPI enhanced prediction within a liver transplantation model, whereas IL-6 before transplantation was significantly associated with recipient 3-year survival. Clinicaltrials.gov: NCT00987714.

Indexed as

AdultBiomarkersBrain DeathFemaleGraft RejectionGraft SurvivalHumansInterleukin-6MaleMiddle AgedOrgan TransplantationSecretory Leukocyte Peptidase InhibitorTissue and Organ ProcurementBiomarkersInterleukin-6Secretory Leukocyte Peptidase InhibitorBiomarkerBrain deathClinical trialOrgan donationRisk predictionTransplantation

Identifiers

PMID30172032
PMCPMC6294437

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.