Evidence map›Paper›PMID 30172004›Full record

ArticleNeuroImage2018

Amygdala habituation and uncinate fasciculus connectivity in adolescence: A multi-modal approach.

Tyler C Hein, Whitney I Mattson, Hailey L Dotterer, Colter Mitchell, Nestor Lopez-Duran, Moriah E Thomason, Scott J Peltier, Robert C Welsh, Luke W Hyde, Christopher S Monk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  14. Morphological similarity of amygdala-ventral prefrontal pathways represents trait anxiety in younger and older adults.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tyler C HeinDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Whitney I MattsonDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA; Center for Behavioral Health at the Research Institute of Nationwide Children's Hospital, Columbus, OH, USA.
Hailey L DottererDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Colter MitchellSurvey Research Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Population Studies Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Nestor Lopez-DuranDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Moriah E ThomasonDepartment of Pediatrics, Wayne State University, Detroit, MI, USA; Merrill Palmer Skillman Institute for Child and Family Development, Wayne State University, Detroit, MI, USA.
Scott J PeltierFunctional MRI Laboratory, University of Michigan, Ann Arbor, MI, USA.
Robert C WelshDepartment of Psychiatry, University of Utah, Salt Lake City, UT, USA.
Luke W HydeDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA; Survey Research Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA.
Christopher S MonkDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA; Survey Research Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address: csmonk@umich.edu.

Funding

TRAINING PROGRAM IN DEVELOPMENTAL PSYCHOLOGYT32HD007109 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GELMAN, SUSAN A., MONK, CHRISTOPHER STEPHEN · 1985 to 2025
$6.6M
Effects of poverty on affective development: A multi-level, longitudinal studyR01MH103761 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MONK, CHRISTOPHER STEPHEN · 2014 to 2018
$3.3M
MRI Scanner for Functional Brain ImagingS10OD012240 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOLL, DOUGLAS C · 2012 to 2012
$2.0M
NICHD NIH HHS T32 HD007109NIH HHS S10 OD012240NIMH NIH HHS R01 MH103761
6 · The paper itself

Abstract

Despite prior extensive investigations of the interactions between the amygdala and prefrontal cortex, few studies have simultaneously considered activation and structural connectivity in this circuit, particularly as it pertains to adolescent socioemotional development. The current multi-modal study delineated the correspondence between uncinate fasciculus (UF) connectivity and amygdala habituation in a large adolescent sample that was drawn from a population-based sample. We then examined the influence of demographic variables (age, gender, and pubertal status) on the relation between UF connectivity and amygdala habituation. 106 participants (15-17 years) completed DTI and an fMRI emotional face processing task. Left UF fractional anisotropy was associated with left amygdala habituation to fearful faces, suggesting that increased structural connectivity of the UF may facilitate amygdala regulation. Pubertal status moderated this structure-function relation, such that the association was stronger in those who were less mature. Therefore, UF connectivity may be particularly important for emotion regulation during early puberty. This study is the first to link structural and functional limbic circuitry in a large adolescent sample with substantial representation of ethnic minority participants, providing a more comprehensive understanding of socioemotional development in an understudied population.

Indexed as

AmygdalaPrefrontal CortexWhite MatterAdolescentAdolescent DevelopmentDiffusion Tensor ImagingEmotionsFacial ExpressionFemaleFunctional NeuroimagingHabituation, PsychophysiologicHumansMaleNeural PathwaysPubertyAdolescenceAmygdalaDTIEmotionfMRI

Identifiers

PMID30172004
PMCPMC6197897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.