ReviewJournal of clinical pharmacy and therapeutics2019
Outcome measures for adherence data from a medication event monitoring system: A literature review.
Review in Journal of clinical pharmacy and therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02585258 (The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study Comparing the Cost-effectiveness and Safety of Additional Low-dose Glucocorticoid in Treatment Strategies for Elderly Patients With Rheumatoid Arthritis), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study Comparing the Cost-effectiveness and Safety of Additional Low-dose Glucocorticoid in Treatment Strategies for Elderly Patients With Rheumatoid Arthritis
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Trial
- Medication adherence in older people with rheumatoid arthritis is lower according to electronic monitoring than according to pill count.Rheumatology (Oxford, England) · 2021Trial
- Effect of a smartphone application (Perx) on medication adherence and clinical outcomes: a 12-month randomised controlled trial.BMJ open · 2021Trial
- Implementing objective monitoring approaches to capture daily opioid usage and postoperative outcomes.Pain medicine (Malden, Mass.) · 2026Article
- Partial non-adherence to antidiabetic therapy undermines diabetes management and correlates with treatment complexity: A cross-sectional study using blood plasma analysis.Diabetes, obesity & metabolism · 2026Article
- Article
- Feasibility and acceptability of self-directed, remote dim-light melatonin onset collection in pediatric patients diagnosed with chronic pain.Frontiers in sleep · 2025Article
- Changed sleep according to weighted blanket adherence in a 16-week sleep intervention among children with attention-deficit/hyperactivity disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Toward Concurrent Identification of Human Activities with a Single Unifying Neural Network Classification: First Step.Sensors (Basel, Switzerland) · 2024Article
- Electronic Real-Time Monitoring Reveals Limited Adherence to Long-Term Opioid Prescriptions in Pain Patients.Journal of pain research · 2024Article
- Association Between Persistence with Oral Atypical Antipsychotic Medications and Hospital and Emergency Department Utilization in Medicaid Patients with Schizophrenia.Patient preference and adherence · 2024Article
- Intake Patterns and Experiences of Patients Using Direct Oral Anticoagulants Measured by Electronic Monitoring in Community Pharmacies.Patient preference and adherence · 2024Article
- Pairwise comparisons of three medication adherence outcomes in adolescents who use alcohol.Alcohol, clinical & experimental research · 2023Article
- Examining factors that influence medication adherence with children seen at outpatient department in Western China: a cross-sectional survey.Scientific reports · 2023Article
- Impact of chronic potassium binder treatment on the clinical outcomes in patients with hyperkalemia: Results of a nationwide hospital-based cohort study.Frontiers in physiology · 2023Article
- Imagine to Remember: An Episodic Future Thinking Intervention to Improve Medication Adherence in Patients with Type 2 Diabetes.Patient preference and adherence · 2022Article
- The Road to Better Management in Resistant Hypertension-Diagnostic and Therapeutic Insights.Pharmaceutics · 2021Review
- Treatment Adherence in Chronic Conditions during Ageing: Uses, Functionalities, and Cultural Adaptation of the Assistant on Care and Health Offline (ACHO) in Rural Areas.Journal of personalized medicine · 2021Article
- Response and Adherence to Nilotinib in Daily practice (RAND study): an in-depth observational study of chronic myeloid leukemia patients treated with nilotinib.European journal of clinical pharmacology · 2020Observational
- Validation of a Novel Electronic Device for Medication Adherence Monitoring of Ambulatory Patients.Pharmacy (Basel, Switzerland) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
what is knownCurrently, medication bottles with an electronic cap are frequently used to measure medication adherence. This system is termed medication event monitoring system (MEMS). To our knowledge, the optimal method to summarize data from MEMS has not yet been determined.
objectiveLook for best practices on how to quantify adherence data from MEMS.
methodsReview of PubMed, Embase and Cochrane databases for the articles on medication adherence with MEMS.
resultsOf 1493 identified articles, 207 were included in this review. The MEMS cap was used for a median of 3 months (IQR: 4; range: 1 week to 24 months) in various health conditions. Many different outcome measures were used. Most studies computed an adherence score, expressed as the percentage of days on which the correct dose of medication was taken. The threshold to mark people as adherent was most frequently, arbitrarily, set at 80% (range: 67%-95%). We found no data to support a specific threshold. DISCUSSION: Although the commonly used definition of adherence has face validity, we found no validation studies, and not all studies used the same cut-off for adherence. Ideally, a cut-off should be defined and validated in the context of the specific drug and its pharmacokinetic and dynamic characteristics, and perhaps other contextual factors, rather than generically. In addition, there was large heterogeneity in the definition of what "correct intake" of medication is. WHAT IS NEW AND
conclusionOutcome measures for MEMS data lacked standardization, and no demonstrable effort to validate any definition against a relevant clinical outcome is available. Consensus on the definition of adherence is urgently needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.