ArticleMethods in molecular biology (Clifton, N.J.)2018
In Vitro Multiexon Skipping by Antisense PMOs in Dystrophic Dog and Exon 7-Deleted DMD Patient.
Akinori Nakamura, Yoshitsugu Aoki, Maria Tsoumpra, Toshifumi Yokota, Shin'ichi Takeda
Open access · greenAbstract read
In one paragraphArticle in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors at 3 institutions in 2 countries.
Akinori NakamuraThird Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan. anakamu@shinshu-u.ac.jp.
Yoshitsugu AokiDepartment of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Maria TsoumpraDepartment of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Toshifumi YokotaDepartment of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry, Edmonton, AB, Canada.
Shin'ichi TakedaDepartment of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
National Center of Neurology and Psychiatry · JPShinshu University · JPUniversity of Alberta · CA
Funding
NCMRR-DC Core Molecular & Functional Outcome Measures in Rehabilitation MedicineR24HD050846 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI KNOBLACH, SUSAN M · 2005 to 2014
$8.6MRNA fidelity and protein function of Becker-like in-frame deletionsP50AR060836 · NIAMS · CHILDREN'S RESEARCH INSTITUTE · PI HOFFMAN, ERIC P. · 2011 to 2015
$7.8MPreclinical dosing optimization: Dosing schedule, tissueU54HD071601 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VAN DEN ANKER, JOHN NICOLAAS · 2011 to 2015
$4.0MGenetics and Genomics of Muscle Postdoctoral Training ProgramT32AR056993 · NIAMS · CHILDREN'S RESEARCH INSTITUTE · PI JAISWAL, JYOTI K, PARTRIDGE, TERENCE A · 2010 to 2019
$2.2MPreclinical drug trial in mouse models of inflammationK26OD011171 · OD · STATE UNIVERSITY OF NY,BINGHAMTON · PI NAGARAJU, KANNEBOYINA · 2012 to 2015
$420kNIAMS NIH HHS P50 AR060836NIAMS NIH HHS T32 AR056993NICHD NIH HHS R24 HD050846NICHD NIH HHS U54 HD071601NIH HHS K26 OD011171
6 · The paper itselfAbstract
Antisense oligonucleotide induced exon skipping emerges as a promising therapeutic strategy for patients suffering from a devastating muscle disorder Duchenne muscular dystrophy (DMD). Systemic administration of antisense phosphorodiamidate morpholino oligomers (PMOs) targeting exons 6 and 8 in dystrophin mRNA of the canine X-linked muscular dystrophy model in Japan (CXMD
Indexed as
ExonsRNA SplicingAnimalsCells, CulturedDogsDystrophinFibroblastsGenetic TherapyGenetic VectorsHumansMorpholinosMuscular Dystrophy, DuchenneMyoblastsMyoD ProteinOligonucleotides, AntisenseRetroviridaeDystrophinMorpholinosMyoD1 myogenic differentiation proteinMyoD ProteinOligonucleotides, AntisenseAntisense oligonucleotideCanine X-linked muscular dystrophy in Japan (CXMDJ)Duchenne/Becker muscular dystrophies (DMD/BMD)DystrophinExon skippingMultiexon skippingPhosphorodiamidate morpholino oligomers (PMOs)
Identifiers
PMID30171540
PMCPMC6557157
OpenAlexW2889462798
What OpenQuestion holds
Textmetadata
LicenceTDM
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