ArticleSurgical endoscopy2019
Persistent dysphagia is a rare problem after laparoscopic Nissen fundoplication.
Article in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Reactive hyperperfusion after short gastric artery division: a real-time indocyanine green fluorescence-guided approach to laparoscopic fundoplication - a case report.International journal of surgery case reports · 2026Article
- Gastrointestinal Complaints After Fundoplication: Rapid Review and Evidence Mapping.Current gastroenterology reports · 2026Review
- Reflections on surgery for hiatal hernia.Updates in surgery · 2026Review
- Ligamentum Teres Repair of Hiatal Hernias in Patients Undergoing Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2026Article
- Validation of Padova Classification of Post-Fundoplication Outflow Obstruction on High-Resolution Manometry in an International Multi-Center Study.Neurogastroenterology and motility · 2025Article
- Postoperative dysphagia and short-term outcomes following laparoscopic floppy Nissen fundoplication combined with V-flap suturing.BMC gastroenterology · 2025Article
- Revisiting Short Gastric Division for Laparoscopic Nissen Fundoplication: A Literature Review.Cureus · 2025Review
- Long-term efficacy and quality of life after antireflux surgery.Surgical endoscopy · 2025Article
- Current management of gastro-oesophageal reflux disease-treatment costs, safety profile, and effectiveness: a narrative review.Gastroenterology report · 2023Review
- Crural closure, not fundoplication, results in a significant decrease in lower esophageal sphincter distensibility.Surgical endoscopy · 2022Article
- Additional fundophrenicopexia, after Nissen fundoplication, reduces postoperative dysphagia and re-operation rate in the long-term follow up.Surgical endoscopy · 2022Article
- Severe dysphagia after antireflux surgery: a rare case of esophageal hiatal stenosis.Clinical journal of gastroenterology · 2021Article
- Ineffective Esophageal Motility in Patients with GERD is no Contraindication for Nissen Fundoplication.World journal of surgery · 2020Article
- Tailored modern GERD therapy - steps towards the development of an aid to guide personalized anti-reflux surgery.Scientific reports · 2019Article
- Quantitative assessment of crural closure for laparoscopic anti-reflux surgeries: A novel technique to reduce post-operative dysphagia.Journal of minimal access surgeryArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough around 30% of patients with gastroesophageal reflux disease (GERD) are insufficiently treated with medical therapy, only 1% opt for surgical therapy. One of the reasons behind this multifactorial phenomenon is the described adverse effect of long-term dysphagia or gastric bloating syndrome after surgical treatment. Aim of this study was to evaluate the most common side effects associated with anti-reflux surgery, as well as long-term outcomes in a large cohort of highly surgically standardized patients after laparoscopic Nissen fundoplication (LNF).
methodsOut of a prospective patients' database including all patients that underwent anti-reflux surgery between 01/2003 and 01/2017 at our institution, 350 consecutive patients after highly standardized LNF were included in this study. A standardized interview was performed by one physician assessing postoperative gastrointestinal symptoms, proton pump inhibitor intake (PPI), GERD-Health-Related-Quality-of-Life (GERD-HRQL), Alimentary Satisfaction (AS), and patients' overall satisfaction.
resultsAfter a median follow-up of 4 years, persistent dysphagia (PD) after LNF was observed in 8 (2%) patients, while postoperative gas-bloat syndrome in 45 (12.7%) cases. Endoscopic dilatation was needed in 7 (2%) patients due to dysphagia, and 19 (5%) patients underwent revision surgery due to recurrence of GERD. The postoperative GERD-HRQL total score was significantly reduced (2 (IQR 0-4.3) vs. 19 (IQR 17-32); p < 0.000) and the median AS was 9/10. Heartburn relief was achieved in 83% of patients. Eighty-three percent of patients were free of PPI intake after follow-up, whereas 13% and 4% of the patients reported daily and irregular PPI use, respectively.
conclusionLNF is a safe and effective surgical procedure with low postoperative morbidity rates and efficient GERD-related symptom relief. PD does not represent a relevant clinical issue when LNF is performed in a surgical standardized way. These results should be the benchmark to which long-term outcomes of new surgical anti-reflux procedures are compared.
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