Evidence map›Paper›PMID 30171385›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2018

Effects of 3,3'-Iminodipropionitrile on Hair Cell Numbers in Cristae of CBA/CaJ and C57BL/6J Mice.

Brent A Wilkerson, Filippo Artoni, Colby Lea, Kayla Ritchie, Catherine A Ray, Olivia Bermingham-McDonogh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Brent A WilkersonDepartment of Biological Structure, University of Washington, 1959 NE Pacific St., Box 357420, Seattle, WA, 98195, USA.
Filippo ArtoniDepartment of Biological Structure, University of Washington, 1959 NE Pacific St., Box 357420, Seattle, WA, 98195, USA.
Colby LeaDepartment of Biological Structure, University of Washington, 1959 NE Pacific St., Box 357420, Seattle, WA, 98195, USA.
Kayla RitchieDepartment of Biological Structure, University of Washington, 1959 NE Pacific St., Box 357420, Seattle, WA, 98195, USA.
Catherine A RayDepartment of Biological Structure, University of Washington, 1959 NE Pacific St., Box 357420, Seattle, WA, 98195, USA.
Olivia Bermingham-McDonoghDepartment of Biological Structure, University of Washington, 1959 NE Pacific St., Box 357420, Seattle, WA, 98195, USA. oliviab@uw.edu.ORCID 0000-0002-2559-4218
University of Washington · USCalifornia Institute for Regenerative Medicine · US

Funding

Auditory Neuroscience Traning ProgramT32DC005361 · NIDCD · UNIVERSITY OF WASHINGTON · PI Adrian KC Lee, DAVID J PERKEL · 2002 to 2026
$8.8M
Regeneration in the vestibular systemR21DC010862 · NIDCD · UNIVERSITY OF WASHINGTON · PI BERMINGHAM-MCDONOGH, OLIVIA MARY · 2010 to 2011
$449k
Mapping cis-acting elements enhancing prosensory gene expressionF32DC016480 · NIDCD · UNIVERSITY OF WASHINGTON · PI WILKERSON, BRENT ALLEN · 2017 to 2018
$118k
NIDCD NIH HHS F32 DC016480NIDCD NIH HHS R21 DC010862NIDCD NIH HHS T32 DC005361
6 · The paper itself

Abstract

This study examines absolute hair cell numbers in the cristae of C57BL/6J mice and CBA/CaJ mice from weaning to adulthood as well as the dose required for 3,3'-iminodiproprionitrile (IDPN)-injury of the cristae in C57BL/6J mice and CBA/CaJ mice, the two mouse strains most commonly used by inner ear researchers. In cristae of CBA/CaJ and C57BL/6J mice, no loss of hair cells was observed up to 24 weeks. In both strains, dose-dependent loss of hair cells was observed 7 days after IDPN treatment of 2-month-old mice (IC

Indexed as

AnimalsCell CountDose-Response Relationship, DrugHair Cells, AuditoryMaleMiceMice, Inbred C57BLMice, Inbred CBANitriles3,3'-iminodipropionitrileNitrilescristaehair cellIDPNmousetoxicityvestibular

Identifiers

PMID30171385
PMCPMC6226411
OpenAlexW2889554164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.