ArticleMagma (New York, N.Y.)2019
Evaluation of atrial septal defects with 4D flow MRI-multilevel and inter-reader reproducibility for quantification of shunt severity.
Article in Magma (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Deep Learning Automated Measurement of Shunt Severity with Estimation of Uncertainty in 4D Flow MRI.Radiology. Cardiothoracic imaging · 2026Article
- Right-to-left shunt detection in patent foramen ovale: The value of synchronized contrast transcranial Doppler and contrast transthoracic echocardiography.World journal of radiology · 2025Article
- Secundum atrial septal defect closure in adults in the UK.European heart journal. Quality of care & clinical outcomes · 2025Observational
- Ferumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Review
- A prediction model of echocardiographic variables to screen for potentially correctable shunts in adult atrial septal defect-pulmonary hypertension patients.Journal of the Chinese Medical Association : JCMA · 2025Article
- Technical Recommendations for Computed Tomography Guidance of Intervention in the Right Ventricular Outflow Tract: Native RVOT, Conduits, and Bioprosthetic Valves.World journal for pediatric & congenital heart surgery · 2023Article
- Resolution of Trifascicular Heart Block with Effective Closure of Congenital Atrial Septal Defect Followed by Later Coronavirus Disease 2019-associated Cardiac Strain.The Journal of innovations in cardiac rhythm management · 2023Article
- Usefulness of a Pulse Oximeter and Multimodality Imaging for Diagnosing Platypnea-orthodeoxia Syndrome.Internal medicine (Tokyo, Japan) · 2023Article
- Repeatability and reproducibility of various 4D Flow MRI postprocessing software programs in a multi-software and multi-vendor cross-over comparison study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- The current state and potential innovation of fetal cardiac MRI.Frontiers in pediatrics · 2023Review
- Impact of ferumoxytol vs gadolinium on 4D flow cardiovascular magnetic resonance measurements in small children with congenital heart disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Article
- Kat-ARC accelerated 4D flow CMR: clinical validation for transvalvular flow and peak velocity assessment.European radiology experimental · 2022Observational
- The role of 4D flow MRI for clinical applications in cardiovascular disease: current status and future perspectives.Quantitative imaging in medicine and surgery · 2021Review
- A prediction model of simple echocardiographic variables to screen for potentially correctable shunts in adult patients with pulmonary arterial hypertension associated with atrial septal defects: a cross-sectional study.The international journal of cardiovascular imaging · 2021Article
- 4D Flow MRI Quantification of Congenital Shunts: Comparison to Invasive Catheterization.Radiology. Cardiothoracic imaging · 2021Article
- Pathology and Advanced Imaging-Characterization of a Congenital Cardiac Defect and Complex Hemodynamics in a Pig: A Case Report.Frontiers in veterinary science · 2021Article
- Left ventricular global longitudinal strain in bicupsid aortic valve patients: head-to-head comparison between computed tomography, 4D flow cardiovascular magnetic resonance and speckle-tracking echocardiography.The international journal of cardiovascular imaging · 2020Observational
- 4-Dimensional Flow by Cardiac Magnetic Resonance Informs Surgical Planning in Partial Anomalous Pulmonary Venous Return.JACC. Case reports · 2020Article
- 4D Flow Vorticity Visualization Predicts Regions of Quantitative Flow Inconsistency for Optimal Blood Flow Measurement.Radiology. Cardiothoracic imaging · 2020Article
- Validation of 4D flow CMR against simultaneous invasive hemodynamic measurements: a swine study.The international journal of cardiovascular imaging · 2019Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWith the hypothesis that 4D flow can be used in evaluation of cardiac shunts, we seek to evaluate the multilevel and interreader reproducibility of measurements of the blood flow, shunt fraction and shunt volume in patients with atrial septum defect (ASD) in practice at multiple clinical sites. MATERIALS AND
methodsFour-dimensional flow MRI examinations were performed at four institutions across Europe and the US. Twenty-nine patients (mean age, 43 years; 11 male) were included in the study. Flow measurements were performed at three levels (valve, main artery and periphery) in both the pulmonary and systemic circulation by two independent readers and compared against stroke volumes from 4D flow anatomic data. Further, the shunt ratio (Q
resultsMeasurements of the pulmonary blood flow at multiple levels correlate well whether measuring at the valve, main pulmonary artery or branch pulmonary arteries (r = 0.885-0.886). Measurements of the systemic blood flow show excellent correlation, whether measuring at the valve, ascending aorta or sum of flow from the superior vena cava (SVC) and descending aorta (r = 0.974-0.991). Intraclass agreement between the two observers for the flow measurements varies between 0.96 and 0.99. Compared with stroke volume, pulmonic flow is underestimated with 0.26 l/min at the main pulmonary artery level, and systemic flow is overestimated with 0.16 l/min at the ascending aorta level. Direct measurements of ASD flow are feasible in 20 of 29 (69%) patients.
conclusionBlood flow and shunt quantification measured at multiple levels and performed by different readers are reproducible and consistent with 4D flow MRI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.