Evidence map›Paper›PMID 30171365›Full record

ReviewThe journal of headache and pain2018

Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH).

Simona Sacco, Gabriele S Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Andreas R Gantenbein, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E Anne MacGregor and 10 more

Open access · goldAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Sex-specific considerations in migraine therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  5. Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  6. Review
  7. Review
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Role of ATP in migraine mechanisms: focus on P2X3 receptors.The journal of headache and pain · 2023
    Review
  15. Review
  16. Article
  17. Contraception During Perimenopause: Practical Guidance.International journal of women's health · 2022
    Review
  18. Adherence to Oral Contraception in Young Women: Beliefs, Locus of Control, and Psychological Reactance.International journal of environmental research and public health · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 12 institutions in 11 countries.

Simona SaccoDepartment of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy. simona.sacco@univaq.it.ORCID http://orcid.org/0000-0003-0651-1939
Gabriele S Merki-FeldClinic for Reproductive Endocrinology, Department of Gynecology, University Hospital, Zürich, Switzerland.
Karen Lehrmann ÆgidiusDepartment of Neurology, Bispebjerg Hospital and University of Copenhagen, Copenhagen, Denmark.
Johannes BitzerDepartment of Obstetrics and Gynecology, University Hospital of Basel, Basel, Switzerland.
Marianne CanonicoUniversité Paris-Saclay, University Paris-Sud, UVSQ, CESP, Inserm UMRS1018, Paris, France.
Andreas R GantenbeinNeurology & Neurorehabilitation, RehaClinic, Bad Zurzach, University of Zurich, Zürich, Switzerland.
Tobias KurthInstitute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Christian LamplHeadache Medical Center Seilerstaette Linz, Linz, Austria.
Øjvind LidegaardDepartment of Obstetrics & Gynaecology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
E Anne MacGregorCentre for Neuroscience & Trauma, BICMS, Barts and the London School of Medicine and Dentistry, London, UK.
Antoinette MaassenVanDenBrinkErasmus Medical Center Rotterdam, Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, Rotterdam, The Netherlands.
Dimos-Dimitrios MitsikostasDepartment of Neurology, University of Athens, Athens, Greece.
Rossella Elena NappiResearch Centre for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
George NtaiosDepartment of Medicine, University of Thessaly, Larissa, Greece.
Koen PaemeleireDepartment of Neurology, Ghent University Hospital, Ghent, Belgium.
Per Morten SandsetUniversity Hospital Rikshospitalet, University of Oslo, Oslo, Norway.
Gisela Marie TerwindtDepartment of Neurology, Leiden University Medical Center, Leiden, the Netherlands.
Kjersti Grøtta VetvikDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.
Paolo MartellettiDepartment of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
European Headache Federation (EHF), the European Society of Contraception and Reproductive Health (ESCRH)
University of Copenhagen · DKInserm · FRNational and Kapodistrian University of Athens · GROslo University Hospital · NOUniversity of L'Aquila · ITUniversity of Thessaly · GRAkershus University Hospital · NOKepler Universitätsklinikum · ATLeiden University Medical Center · NLQueen Mary University of London · GBSapienza University of Rome · ITUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was undertaken to develop statements to support clinical decision making, in terms of possible effects on migraine course of exogenous estrogens and progestogens and on possible treatment of headache associated with the use or with the withdrawal of hormones. Overall, quality of current evidence is low. Recommendations are provided for all the compounds with available evidence including the conventional 21/7 combined hormonal contraception, the desogestrel only oral pill, combined oral contraceptives with shortened pill-free interval, combined oral contraceptives with estradiol supplementation during the pill-free interval, extended regimen of combined hormonal contraceptive with pill or patch, combined hormonal contraceptive vaginal ring, transdermal estradiol supplementation with gel, transdermal estradiol supplementation with patch, subcutaneous estrogen implant with cyclical oral progestogen. As the quality of available data is poor, further research is needed on this topic to improve the knowledge about the use of estrogens and progestogens in women with migraine. There is a need for better management of headaches related to the use of hormones or their withdrawal.

Indexed as

ConsensusContraceptionContraceptives, Oral, CombinedDesogestrelEstrogensEuropeFemaleHeadacheHumansMigraine DisordersProgestinsReproductive HealthSocieties, MedicalContraceptives, Oral, CombinedDesogestrelEstrogensProgestinsContraceptionEstrogensHeadacheHormonal contraceptivesMigraineProgestogens

Identifiers

PMID30171365
PMCPMC6119173
OpenAlexW2889390659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.