Evidence map›Paper›PMID 30171282›Full record

ArticleAnalytical and bioanalytical chemistry2018

Minimally invasive technique for measuring transdermal glucose with a fluorescent biosensor.

Sheniqua Brown, Paige N Zambrana, Xudong Ge, Dayanand Bagdure, Audra L Stinchcomb, Govind Rao, Leah Tolosa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Microneedles: Selected Applications for Pediatrics.Children (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Review
  5. Advances in Biosensors for Continuous Glucose Monitoring Towards Wearables.Frontiers in bioengineering and biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sheniqua BrownCenter for Advanced Sensor Technology Research (CAST), Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD, 21250, USA.
Paige N ZambranaDepartment of Pharmaceutical Sciences, University of Maryland, 20 North Pine Street, Baltimore, MD, 21201, USA.
Xudong GeCenter for Advanced Sensor Technology Research (CAST), Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD, 21250, USA.
Dayanand BagdureDepartment of Pediatrics, University of Maryland Medical Center, 110 S Paca Street, Baltimore, MD, 21201, USA.
Audra L StinchcombDepartment of Pharmaceutical Sciences, University of Maryland, 20 North Pine Street, Baltimore, MD, 21201, USA.
Govind RaoCenter for Advanced Sensor Technology Research (CAST), Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD, 21250, USA.
Leah TolosaCenter for Advanced Sensor Technology Research (CAST), Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD, 21250, USA. leah@umbc.edu.
University of Maryland, Baltimore County · USUniversity of Maryland, Baltimore · USUniversity of Maryland Medical Center · US

Funding

EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
Painless, Bloodless And Safe Glucose Sensing System For The Pediatric Intensive Care UnitR41HD088223 · NICHD · FLUOROMETRIX BIOMEDICAL COMPANY · PI POTTS, RUSSELLL O, TOLOSA, LEAH · 2016 to 2016
$150k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R41HD088223NICHD NIH HHS R41 HD088223NIGMS NIH HHS R25 GM055036
6 · The paper itself

Abstract

There is a need for blood glucose monitoring techniques that eliminate the painful and invasive nature of current methods, while maintaining the reliability and accuracy of established medical technology. This research aims to ultimately address these shortcomings in critically ill pediatric patients. Presented in this work is an alternative, minimally invasive technique that uses microneedles (MN) for the collection of transdermal glucose (TG). Due to their comparable skin properties, diffusion studies were performed on full thickness Yucatan miniature pig skin mounted to an in-line diffusion flow cell and on different skin sites of human subjects. Collected TG samples were measured with a L255C mutant of the E. coli glucose-binding protein (GBP) with an attached fluorescent probe. The binding constant (K

Indexed as

NeedlesAdultAnimalsBiosensing TechniquesBlood GlucoseBlood Glucose Self-MonitoringDiffusionEquipment DesignEscherichia coliEscherichia coli ProteinsFluorescent DyesHumansReproducibility of ResultsSkinSwineSwine, MiniatureBlood GlucoseEscherichia coli ProteinsFluorescent DyesIn-line flow through diffusion cellMicroneedlesOptical biosensorTransdermal glucose monitoring

Identifiers

PMID30171282
PMCPMC6348894
OpenAlexW2889556943

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.