Evidence map›Paper›PMID 30171226›Full record

ArticleEuropean journal of clinical nutrition2019

Neonatal thyrotropin (TSH) screening as a tool for monitoring iodine nutrition in Armenia.

Nicholas Hutchings, Irina Tovmasyan, Marine Hovsepyan, Mushegh Qefoyan, Sisak Baghdasaryan, John P Bilezikian

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicholas HutchingsDepartment of Endocrinology, Yerevan State Medical University, Yerevan, Armenia. nicholas.hutchings@uci.edu.ORCID http://orcid.org/0000-0001-9964-142X
Irina TovmasyanNeonatal Screening Program, Arabkir Medical Center, Yerevan, Armenia.
Marine HovsepyanLaboratory Service, Arabkir Medical Center, Yerevan, Armenia.
Mushegh QefoyanNational Institute of Health, Ministry of Health, Yerevan, Armenia.
Sisak Baghdasaryan
John P BilezikianCollege of Physicians & Surgeons, Columbia University, New York, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal thyrotropin (TSH) is influenced not only by the infant's own thyroid function, but also by maternal thyroid status, and can thus provide a general index of thyroid health in the community.

methodsIn 2012, the Republic of Armenia implemented a program of universal neonatal hypothyroidism screening by means of measuring the serum TSH level. The Arabkir Medical Center in Yerevan, Armenia, has maintained records of neonatal TSH screening data comprising nearly 100% of all births in Armenia from 2012 through 2016. We analyzed these data to determine the frequency of neonatal TSH levels higher than the cut point of 5 mIU/L, indicative of sufficient iodine nutrition status, and to detect any time dependence over years or regional variation.

resultsA total of 127,177 records from 2012 to 2016 were included. The geographic distribution of neonatal TSH records was reflective of the population of Armenia; the national percentage of records over 5 mIU/L ranged from a high of 2.88% in 2012 to a low of 1.71% in 2016. Minimal regional variation was noted, from a 2012-2016 cumulative high of 2.93% of records over 5 mIU/L in Shirak province to a low of 0.95% in the Vayots Dzor province.

conclusionsFrom all years and from all regions, values were consistently and uniformly below the cut point of 5 mIU/L. These results show no evidence of iodine deficiency in Armenia, and suggest that neonatal TSH may be a useful tool for monitoring iodine nutrition in Armenia.

Indexed as

Neonatal ScreeningArmeniaCongenital HypothyroidismFemaleHumansInfant, NewbornIodineMaleNutritional StatusThyrotropinIodineThyrotropin

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.