Evidence map›Paper›PMID 30171224›Full record

ArticleBone marrow transplantation2019

A dynamical systems perspective on chimeric antigen receptor T-cell dosing.

Amir A Toor, Alden Chesney, Jamal Zweit, Jason Reed, Shahrukh K Hashmi

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. CARTCancers · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Amir A ToorBone Marrow Transplant Program, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. amir.toor@vcuhealth.org.
Alden ChesneyDepartment of Pathology, Virginia Commonwealth University, Richmond, VA, USA.
Jamal ZweitDepartment of Radiology, Virginia Commonwealth University, Richmond, VA, USA.
Jason ReedDepartment of Physics, Virginia Commonwealth University, Richmond, VA, USA.
Shahrukh K HashmiDivision of Hematology, Dept. of Medicine, Mayo Clinic, Rochester, MN, USA.
Virginia Commonwealth University · USSaudi Center for Organ Transplantation · SA

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
(PQD5) Mass Profiling Melanoma Responses to Improve Therapy Choices and PrognosisR01CA185189 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, JASON C, TEITELL, MICHAEL A · 2014 to 2017
$1.9M
NCI NIH HHS P30 CA016059NCI NIH HHS R01 CA185189
6 · The paper itself

Abstract

Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. However, the mechanism driving proliferation in CAR T cells is distinct from conventional T cells. As such there are quantitative differences in the antigen response of these engineered cells when compared with conventional T cells. In this perspective paper the logistic equation of growth is used to develop a mathematical basis for understanding the difference between CAR T cell and conventional T cell response to antigen burden.

Indexed as

HumansReceptors, Antigen, T-CellReceptors, Chimeric AntigenReceptors, Antigen, T-CellReceptors, Chimeric Antigen

Identifiers

PMID30171224
OpenAlexW2801411500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.