ArticleMolecular & cellular proteomics : MCP2018
Hepatic Mitochondrial Defects in a Nonalcoholic Fatty Liver Disease Mouse Model Are Associated with Increased Degradation of Oxidative Phosphorylation Subunits.
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Article in Molecular & cellular proteomics : MCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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Who cites it
52 citing papers in PubMed, 80 citations in OpenAlex.
- Metreleptin therapy for nonalcoholic steatohepatitis: Open-label therapy interventions in two different clinical settings.Med (New York, N.Y.) · 2021Trial
- Perfluorooctane sulfonic acid (PFOS) perturbs skeletal muscle oxidative phosphorylation by a different mechanism than liver.Chemosphere · 2026Article
- The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).International journal of molecular sciences · 2026Review
- Natural Product Treatment for Metabolic Dysfunction-Associated Steatotic Liver Disease: Targeted Mitochondrial Quality Control.Drug design, development and therapy · 2026Review
- Roles of mitochondrial complexes in non-alcoholic fatty liver disease.Frontiers in molecular biosciences · 2026Review
- Novel therapeutic strategies targeting mitochondrial quality control for metabolic dysfunction-associated steatotic liver disease.Frontiers in physiology · 2026Review
- The Role of Mitochondrial Complexes in Liver Diseases.Journal of clinical and translational hepatology · 2025Review
- A novel palmitoylation-based molecular signature reveals COX6A1 as a key regulator in metabolic dysfunction-associated steatotic liver disease.Journal of translational medicine · 2025Article
- Zebrafish model of palmitic acid induced MAFLD recapitulates pathways conserved in mice and humans.Scientific reports · 2025Article
- Reduced liver mitochondrial energy metabolism impairs food intake regulation following gastric preloads and fasting.Molecular metabolism · 2025Article
- Chronic Alcohol Consumption Reprograms Hepatic Metabolism Through Organelle-Specific Acetylation in Mice.Molecular & cellular proteomics : MCP · 2025Article
- Hyperinsulinemic male LEW.1WR1 rats show early signs of impaired liver metabolism.Experimental and molecular pathology · 2025Article
- Gut microbial metabolites in MASLD: Implications of mitochondrial dysfunction in the pathogenesis and treatment.Hepatology communications · 2024Review
- Consuming a Linoleate-Rich Diet Increases Concentrations of Tetralinoleoyl Cardiolipin in Mouse Liver and Alters Hepatic Mitochondrial Respiration.The Journal of nutrition · 2024Article
- Polyphenols alleviate metabolic disorders: the role of ubiquitin-proteasome system.Frontiers in nutrition · 2024Review
- Molecular and cellular mechanisms underlying the hepatoprotective role of ghrelin against NAFLD progression.Journal of physiology and biochemistry · 2023Review
- Flexible Quality Control for Protein Turnover Rates Using d2ome.International journal of molecular sciences · 2023Article
- Mitochondrial Proteome Changes in Rett Syndrome.Biology · 2023Article
- A high-fat diet increases hepatic mitochondrial turnover through restricted acetylation in a NAFLD mouse model.American journal of physiology. Endocrinology and metabolism · 2023Article
- MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Kwangwon LeeDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272.
Andrew HaddadDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272.
Abdullah OsmeDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272.
Chunki KimDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272.
Ahmad BorzouDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555.
Sergei IlchenkoDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272.
Daniela AllendeDepartment of Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195.
Srinivasan DasarathyDepartment of Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio 44195.
Arthur McCulloughDepartment of Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio 44195.
Rovshan G SadygovDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555.
Takhar KasumovDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272; Department of Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio 44195. Electronic address: tkasumov@neomed.edu.
Northeast Ohio Medical University · USCleveland Clinic · USThe University of Texas Medical Branch at Galveston · US
Funding
Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI LAURA E. NAGY · 2016 to 2026
$19.6MNon Alcoholic Steatohepatitis Clinical Research NetworkU01DK061732 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2002 to 2026
$12.2MIntegrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD)- Cleveland Clinic Clinical CenterU01AA026976 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy, David Streem · 2018 to 2026
$3.2MFollistatin-like protein 1 in cardiac and systemic metabolismR01HL129120 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RECCHIA, FABIO A, WALSH, KENNETH · 2016 to 2019
$2.9MNovel computational methods for in vivo proteome dynamics estimation using heavy water metabolic labeling and LC-MSR01GM112044 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SADYGOV, ROVSHAN G · 2015 to 2023
$2.7MSarcopenia in cirrhosis is mediated by a hyperammonemic stress responseR01DK113196 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN, HATZOGLOU, MARIA · 2018 to 2021
$2.3MMechanisms of Malnutrition in Cirrhosis with Portosystemic ShuntingR01GM119174 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN · 2017 to 2020
$1.2MHyperammonemia reduces skeletal muscle protein synthesis via a beta-catenin-cMyc mediated impaired ribosomal biogenesisR21AR071046 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN, DAVULURI, GANGARAO · 2017 to 2018
$399kAged rat heart mitochondrial dysfunction: proteome and lipidome dynamicsR21AG049461 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI HOPPEL, CHARLES LESLIE · 2015 to 2015
$238kNHLBI NIH HHS R01 HL129120NIAAA NIH HHS P50 AA024333NIAAA NIH HHS U01 AA026976NIAMS NIH HHS R21 AR071046NIA NIH HHS R21 AG049461NIDDK NIH HHS R01 DK113196NIDDK NIH HHS U01 DK061732NIGMS NIH HHS R01 GM112044NIGMS NIH HHS R01 GM119174
Abstract
Nonalcoholic fatty liver disease (NAFLD) is associated with hepatic mitochondrial dysfunction characterized by reduced ATP synthesis. We applied the
Indexed as
MitophagyAnimalsAutophagyDiet, WesternDisease Models, AnimalFatty AcidsHalf-LifeLiverMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial ProteinsNon-alcoholic Fatty Liver DiseaseOxidative PhosphorylationFatty AcidsMitochondrial ProteinsReactive Oxygen SpeciesEnergy metabolismheavy waterMass Spectrometrymetabolic labelingMitochondria function or biologyoxidative phosphorylationOxidative stressProtein DegradationProtein Turnover
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.