ArticleScience immunology2018
Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria.
Abstract read
In one paragraph
Article in Science immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Short-term evaluation of immune levels and nutritional values of EN versus PN in gastric cancer: a systematic review and a meta-analysis.World journal of surgical oncology · 2019Pooled it
- Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies ofMedComm · 2026Review
- Menstruation is Associated With Cyclical Granulysin Peaks in Vaginal Secretions Despite Stable Expression by Cervicovaginal Immune Cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Th17-driven CD8Cell death & disease · 2026Article
- T cell-macrophage interactions in tuberculosis: What we've got here is failure to communicate.Journal of internal medicine · 2026Review
- Interleukin-15 correlates with cytotoxic immune networks in cervical tuberculous lymphadenitis.Frontiers in immunology · 2026Article
- Single-cell transcriptomic profiling of cerebrospinal fluid reveals immune-cell heterogeneity and multicompartment MIF/CD74-related communication in tuberculous and purulent meningitis.Frontiers in cellular and infection microbiology · 2026Article
- Identification of hub gene and immune infiltration in Lyme disease revealed by weighted gene co-expression network analysis and machine learning.European journal of medical research · 2025Article
- CD226 identifies effector CD8Cell reports · 2025Article
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Dynamics of Th1/Th17 responses and antimicrobial pathways in leprosy skin lesions.The Journal of clinical investigation · 2025Article
- Polycytotoxic T cells mediate antimicrobial activity against intracellularInfection and immunity · 2025Article
- Mycobacterium tuberculosis resisters despite HIV exhibit activated T cells and macrophages in their pulmonary alveoli.The Journal of clinical investigation · 2025Article
- Vγ9Vδ2 T cells expanded with vitamin C combined with HMBPPFrontiers in cellular and infection microbiology · 2025Article
- Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production.Frontiers in immunology · 2025Article
- A natural killer cell mimic against intracellular pathogen infections.Science advances · 2024Article
- Intravenous Bacillus Calmette-Guérin (BCG) Induces a More Potent Airway and Lung Immune Response than Intradermal BCG in Simian Immunodeficiency Virus-infected Macaques.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Intravenous BCG induces a more potent airway and lung immune response than intradermal BCG in SIV-infected macaques.bioRxiv : the preprint server for biology · 2024Article
- IL-15 in T-Cell Responses and Immunopathogenesis.Immune network · 2024Review
- Mechanisms governing bystander activation of T cells.Frontiers in immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
Samuel J BalinDivision of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.ORCID 0000-0002-7646-1319
Matteo PellegriniMolecular Cell and Developmental Biology at UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0001-9355-9564
Eynav KlechevskyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0001-6121-1571
Sohui T WonDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
David I WeissMolecular Biology Interdepartmental Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0002-2068-7036
Aaron W ChoiDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Joshua HakimianDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Jing LuMolecular Cell and Developmental Biology at UCLA, Los Angeles, CA 90095, USA.
Maria Teresa OchoaDepartment of Dermatology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA.ORCID 0000-0001-6550-5008
Barry R BloomHarvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Lewis L LanierDepartment of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-1308-3952
Steffen StengerInstitute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.
Robert L ModlinDivision of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. rmodlin@mednet.ucla.edu.ORCID 0000-0003-4720-031X
University of California, Los Angeles · USHarvard University · USParker Institute for Cancer Immunotherapy · USUniversity Hospital Ulm · DEUniversity of Southern California · USWashington University in St. Louis · US
Funding
Molecular Analysis of the Host Immune Response in LeprosyR01AI022553 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERT L MODLIN · 1989 to 2026
$15.7MTCR GAMMA/DELTA LYMPHOCYTES IN HUMAN SKIN LESIONSR01AR040312 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MODLIN, ROBERT L · 1990 to 2025
$10.4MVitamin D Metabolism in LeprosyP50AR063020 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PELLEGRINI, MATTEO · 2012 to 2016
$7.8MNK MemoryR01AI068129 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2020
$6.0MAnti-TB sterilizing immunity in immune and HIV+ individualsR01HL129887 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHEN, ZHENG W · 2015 to 2018
$2.1MRole of Vitamin D Prohormone 25-OHD in the Immune Response to TuberculosisR01HL119068 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIU, PHILIP T., MODLIN, ROBERT L · 2014 to 2017
$1.5MTricytotoxic T cells protect against intracellular infection in human skinK08AR074552 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BALIN, SAMUEL JACKSON · 2019 to 2020
$256kNHLBI NIH HHS R01 HL119068NHLBI NIH HHS R01 HL129887NIAID NIH HHS R01 AI022553NIAID NIH HHS R01 AI068129NIAMS NIH HHS K08 AR074552NIAMS NIH HHS P50 AR063020NIAMS NIH HHS R01 AR040312
Abstract
Human CD8
Indexed as
Antigens, Differentiation, T-LymphocyteCytokinesGranzymesHumansLeprosyMycobacterium lepraemuriumPerforinReceptors, Natural Killer CellT-Lymphocytes, CytotoxicAntigens, Differentiation, T-LymphocyteCytokinesGNLY protein, humanGranzymesGZMB protein, humanPerforinReceptors, Natural Killer Cell
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.