ArticleInternational journal of hygiene and environmental health2019
Dibutyl-phthalate exposure from mesalamine medications and serum thyroid hormones in men.
Article in International journal of hygiene and environmental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Plasticizing Diabetes Care: The Metabolic Threat of Plastic-Associated Endocrine Disruptors and Micro-/Nanoplastics in Clinical Medicine.Current diabetes reports · 2026Review
- Characterization of DBP contamination in a soil-wheat system and variety-specific tolerance associated with rhizosphere microbial communities.BMC plant biology · 2026Article
- The Plasticizer Dibutyl Phthalate (DBP) Impairs Pregnancy Vascular Health: Insights into Calcium Signaling and Nitric Oxide Involvement.Journal of xenobiotics · 2025Article
- Phthalates and epigenetics: An emerging public health concern.Current research in toxicology · 2025Review
- Review
- Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization.Epigenetics & chromatin · 2023Article
- Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis.Exposome · 2023Article
- Urinary phthalate metabolites in pregnant women: occurrences, related factors, and association with maternal hormones.Environmental science and pollution research international · 2022Article
- Endocrine-Disrupting Chemicals' (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1.International journal of molecular sciences · 2020Review
- Unwitting Accomplices: Endocrine Disruptors Confounding Clinical Care.The Journal of clinical endocrinology and metabolism · 2020Article
- The effects of di-butyl phthalate exposure from medications on human sperm RNA among men.Scientific reports · 2019Article
- High phthalate exposure increased urinary concentrations of quinolinic acid, implicated in the pathogenesis of neurological disorders: Is this a potential missing link?Environmental research · 2019Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundDibutyl phthalate (DBP) is an endocrine disruptor and used in some medication coatings, such as mesalamine for treatment inflammatory bowel disease (IBD).
objectivesTo determine whether high-DBP from some mesalamine medications alters thyroid function.
methodsSeventy men with IBD, without thyroid disease or any radiation history participated in a crossover-crossback prospective study and provided up to 6 serum samples (2:baseline, 2:crossover, 2:crossback). Men on non-DBP mesalamine (background exposure) at baseline crossed-over to DBP-mesalamine (high exposure) then crossed-back to non-DBP mesalamine (B
resultsAfter crossover in B
conclusionsHigh-DBP novel exposure or removal from chronic high-DBP exposure could alter elements of the thyroid system, and most probably alters the peripheral T4 conversion to T3 and thyroid autoimmunity, consistent with thyroid disruption. After exposure removal, these trends were mostly reversed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.