Evidence map›Paper›PMID 30170889›Full record

ReviewTrends in biochemical sciences2018

New Insights into the Molecular Events of Mammalian Fertilization.

Yuhkoh Satouh, Masahito Ikawa

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
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  14. Review
  15. Article
  16. Article
  17. Review
  18. Suppression of Non-Random Fertilization by MHC Class I Antigens.International journal of molecular sciences · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yuhkoh SatouhResearch Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan. Electronic address: yuhkohs@biken.osaka-u.ac.jp.
Masahito IkawaResearch Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan; The Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan. Electronic address: ikawa@biken.osaka-u.ac.jp.

Funding

Targeting sperm-specific proteins during meiosis and sperm morphogenesisP01HD087157 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 2017 to 2021
$6.2M
Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
NICHD NIH HHS P01 HD087157NICHD NIH HHS R01 HD088412
6 · The paper itself

Abstract

Currently, infertility affects ∼16% of couples worldwide. The causes are reported to involve both male and female factors, including fertilization failure between mature spermatozoa and eggs. However, the molecular mechanisms involved in each step of mammalian fertilization are yet to be fully elucidated. Although some of these steps can be rescued with assisted reproductive technologies, it is important to clarify the molecular mechanisms involved for the treatment and diagnosis of infertile couples. This review illustrates recent findings in mammalian fertilization, discovered by combining gene modification techniques with other new approaches, and aims to show how these findings will guide future research in mammalian fertilization.

Indexed as

FertilizationAnimalsCarrier ProteinsClustered Regularly Interspaced Short Palindromic RepeatsEgg ProteinsFemaleHumansImmunoglobulinsMaleMammalsMembrane ProteinsPhosphoinositide Phospholipase CReceptors, Cell SurfaceSpecies SpecificitySperm-Ovum InteractionsCarrier ProteinsEgg ProteinsImmunoglobulinsIZUMO1 protein, humanIZUMO1R protein, humanMembrane ProteinsPhosphoinositide Phospholipase CPLCZ1 protein, humanReceptors, Cell SurfaceCRISPR/Cas9 systemegg activationGenetically modified animalsmammalian fertilizationsperm–egg fusion

Identifiers

PMID30170889
PMCPMC6162164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.