ArticleThe Journal of pediatrics2018
Perinatal Transmission of Hepatitis C Virus: Defining the Cascade of Care.
Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06367465 (Feasibility and Acceptability of Early Linkage to HCV Treatment in Pregnancy Feasibility and Acceptability of Early Linkage to HCV Treatment in Pregnancy), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Acceptability of Early Linkage to HCV Treatment in Pregnancy Feasibility and Acceptability of Early Linkage to HCV Treatment in Pregnancy
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Vertical Transmission of Hepatitis B and C-Then and Now-A Comprehensive Literature Systematic Review.Viruses · 2025Pooled it
- Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection.Hepatology (Baltimore, Md.) · 2020Guideline
- Hepatitis C Virus Testing in Perinatally Exposed Children.JAMA network open · 2026Article
- Review
- Pediatric and Adolescent Hepatitis C Care Cascade and Real-World Treatment Outcomes Utilizing an Integrated Health System Specialty Pharmacy Model.Journal of the Pediatric Infectious Diseases Society · 2025Observational
- Disparities in Linkage to Care Among Children With Hepatitis C Virus in the United States.Pediatrics · 2025Article
- Racial and Ethnic Disparities in Testing of Hepatitis C Virus-Exposed Children Across the United States.Journal of the Pediatric Infectious Diseases Society · 2024Article
- Global epidemiology, natural history, maternal-to-child transmission, and treatment with DAA of pregnant women with HCV: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Prevalence and Modes of Transmission of Hepatitis C Virus Infection: A Historical Worldwide Review.Viruses · 2024Review
- Food Pantry Referral and Utilization in a Pediatric Primary Care Clinic.American journal of preventive medicine · 2024Article
- Maternal neighbourhood-level social determinants of health and their association with paediatric hepatitis C screening among children exposed to hepatitis C in pregnancy.Paediatric and perinatal epidemiology · 2024Article
- Hepatitis C virus detection and management after implementation of universal screening in pregnancy.AJOG global reports · 2024Article
- CDC Recommendations for Hepatitis C Testing Among Perinatally Exposed Infants and Children - United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023Article
- Retrospective analysis of vertical Hepatitis C exposure and infection in children in Western New York.BMC gastroenterology · 2023Article
- Trends in the Prevalence of Hepatitis C Infection During Pregnancy and Maternal-Infant Outcomes in the US, 1998 to 2018.JAMA network open · 2023Article
- Cost-Effectiveness of Strategies to Identify Children with Perinatally Acquired Hepatitis C Infection.The Journal of pediatrics · 2023Article
- Spontaneous Clearance of Vertically Acquired Hepatitis C Infection: Implications for Testing and Treatment.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Overall Vertical Transmission of Hepatitis C Virus, Transmission Net of Clearance, and Timing of Transmission.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Evidence for Implementation: HIV/HCV Coinfection and Pregnancy.Current HIV/AIDS reports · 2023Review
- Prevention of hepatocellular carcinoma and monitoring of high-risk patients.Hepatology forum · 2022Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe US National Viral Hepatitis Action Plan calls for major efforts to expand hepatitis C virus (HCV) diagnosis and treatment; prenatal care settings are potential venues for expanding HCV testing. We aimed to characterize the HCV diagnostic cascade for women and infants and investigate factors associated with linkage and follow-up. STUDY
designWe used electronic health records for a 10-year cohort of 879 women with opioid use disorder from an obstetric clinic serving women with substance use disorders.
resultsAltogether, 744 women (85%) were screened for HCV; 510 (68%) were seropositive, of whom 369 (72%) had nucleic acid testing performed and of these 261 (71%) were viremic. Of 404 infants born to HCV-seropositive women, 273 (68%) were tested at least once for HCV, 180 (45%) completed the American Academy of Pediatrics-recommended perinatal HCV screening, and 5 (2.8%) were diagnosed with HCV infection and linked to care. More recent delivery date (2014-2015) was associated with maternal linkage to care (aOR, 2.5; 95% CI, 1.4-4.7). Maternal coinfection with HIV (aOR, 9.0; 95% CI, 1.1-72.8) and methadone maintenance therapy, compared with buprenorphine (aOR, 1.5; 95% CI, 0.9-2.5), were associated with higher rates of infant HCV testing.
conclusionsHCV prevalence among pregnant women with opioid use is high and infant HCV screening is imperfect. Programmatic changes to improve both mother and infant follow-up may help to bridge identified gaps in the cascade to cure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.