Evidence map›Paper›PMID 30170838›Full record

ArticleJournal of biomechanics2018

Effect of guided bone regeneration on bone quality surrounding dental implants.

Trenton B Johnson, Ben Siderits, Seth Nye, Yong-Hoon Jeong, Seung-Hee Han, In-Chul Rhyu, Jung-Suk Han, Toru Deguchi, F Michael Beck, Do-Gyoon Kim

Open access · bronzeAbstract read
In one paragraph

Article in Journal of biomechanics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Effect of Polylactic Acid Membrane on Guided Bone Regeneration in Anterior Maxillary Implantation.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Effects of Yunnan Baiyao on the Differentiation of HPDLFs on the Bio-OssInternational journal of general medicine · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Trenton B JohnsonDivision of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
Ben SideritsDivision of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
Seth NyeDivision of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
Yong-Hoon JeongDivision of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
Seung-Hee HanPeriodontology, Department of Dental Science, Graduate School, Seoul National University, Seoul, South Korea.
In-Chul RhyuPeriodontology, Department of Dental Science, Graduate School, Seoul National University, Seoul, South Korea.
Jung-Suk HanProsthodontics, Department of Dental Science, Graduate School, Seoul National University, Seoul, South Korea.
Toru DeguchiDivision of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
F Michael BeckDivision of Oral Bioscience, College of Dentistry, Ohio State University, Columbus, OH, USA.
Do-Gyoon KimDivision of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA. Electronic address: kim.2508@osu.edu.
The Ohio State University · USSeoul National University · KR

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
NCATS NIH HHS UL1 TR001070
6 · The paper itself

Abstract

Bone quality as well as its quantity at the implant interface is responsible for determining stability of the implant system. The objective of this study is to examine the nanoindentation based elastic modulus (E) at different bone regions adjacent to titanium dental implants with guided bone regeneration (GBR) treated with DBM and BMP-2 during different post-implantation periods. Six adult male beagle dogs were used to create circumferential defects with buccal bone removal at each implantation site of mandibles. The implant systems were randomly assigned to only GBR (control), GBR with demineralized bone matrix (DBM), and GBR with DBM + recombinant human bone morphogenetic protein-2 (rhBMP-2) (BMP) groups. Three animals were sacrificed at each 4 and 8 weeks of post-implantation healing periods. Following buccolingual dissection, the E values were assessed at the defects (Defect), interfacial bone tissue adjacent to the implant (Interface), and pre-existing bone tissue away from the implant (Pre-existing). The E values of BMP group had significantly higher than control and DBM groups for interface and defect regions at 4 weeks of post-implantation period and for the defect region at 8 weeks (p < 0.043). DBM group had higher E values than control group only for the defect region at 4 weeks (p < 0.001). The current results indicate that treatment of rhBMP-2 with GBR accelerates bone tissue mineralization for longer healing period because the GBR likely facilitates a microenvironment to provide more metabolites with open space of the defect region surrounding the implant.

Indexed as

Bone RegenerationDental ImplantsGuided Tissue Regeneration, PeriodontalAnimalsBone MatrixBone Morphogenetic Protein 2Dental Implantation, EndosseousDogsElastic ModulusMaleMandibleRecombinant ProteinsTitaniumTransforming Growth Factor betaWound HealingBone Morphogenetic Protein 2Dental Implantsrecombinant human bone morphogenetic protein-2Recombinant ProteinsTitaniumTransforming Growth Factor betaBone qualityDental implantGuided bone regenerationNanoindentationrhBMP-2

Identifiers

PMID30170838
PMCPMC6233303
OpenAlexW2888108348

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.