Evidence map›Paper›PMID 30170711›Full record

ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2018

Models of Network Spread and Network Degeneration in Brain Disorders.

Ashish Raj, Fon Powell

Abstract readReview
In one paragraph

Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A co-alteration parceling of the cingulate cortex.Brain structure & function · 2022
    Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  10. Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  11. Variation in high-amplitude events across the human lifespan.Network neuroscience (Cambridge, Mass.) · 2026
    Article
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  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ashish RajDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California. Electronic address: ashish.raj@ucsf.edu.
Fon PowellDepartment of Radiology, Weill Cornell Medicine, New York, New York.
Cornell University · USUniversity of California, San Francisco · US

Funding

Predictive model of spread of Parkinson's pathology using network diffusionR01NS092802 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUPTA, AJAY, RAJ, ASHISH · 2016 to 2020
$2.8M
Multimodal modeling framework for fusing structural and functional connectome dataR01EB022717 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI NAGARAJAN, SRIKANTAN S., RAJ, ASHISH · 2016 to 2018
$1.6M
NIBIB NIH HHS R01 EB022717NINDS NIH HHS R01 NS092802
6 · The paper itself

Abstract

Network analysis can provide insight into key organizational principles of brain structure and help identify structural changes associated with brain disease. Though static differences between diseased and healthy networks are well characterized, the study of network dynamics, or how brain networks change over time, is increasingly central to understanding ongoing brain changes throughout disease. Accordingly, we present a short review of network models of spread, network dynamics, and network degeneration. Borrowing from recent suggestions, we divide this review into two processes by which brain networks can change: dynamics on networks, which are functional and pathological consequences taking place atop a static structural brain network; and dynamics of networks, which constitutes a changing structural brain network. We focus on diffusion magnetic resonance imaging-based structural or anatomic connectivity graphs. We address psychiatric disorders like schizophrenia; developmental disorders like epilepsy; stroke; and Alzheimer's disease and other neurodegenerative diseases.

Indexed as

EpilepsyModels, NeurologicalNerve NetNeurodegenerative DiseasesSchizophreniaStrokeDiffusion Tensor ImagingHumansBrain networksConnectomicsDiffusion tensor imagingGraph theoryNetwork neuroscienceNeural networksNeurodegenerationNeurological diseaseSchizophrenia

Identifiers

PMID30170711
PMCPMC6219468
OpenAlexW2887145400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.