Evidence map›Paper›PMID 30170616›Full record

ArticleItalian journal of pediatrics2018

Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service.

A Orsini, I Sammartino, A Valetto, V Bertini, P Marchese, A Bonuccelli, D G Peroni

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

A OrsiniPediatric Neurology, Pediatric Department, Azienda Ospedaliera Universitaria Pisana, Via Roma 57, 56100, Pisa, Italy.
I SammartinoPediatric Neurology, Pediatric Department, Azienda Ospedaliera Universitaria Pisana, Via Roma 57, 56100, Pisa, Italy.
A ValettoCytogenetics Unit, Medicine of Laboratory Department, Azienda Ospedaliera Universitaria Pisana, Pisa, 56100, Italy.
V BertiniCytogenetics Unit, Medicine of Laboratory Department, Azienda Ospedaliera Universitaria Pisana, Pisa, 56100, Italy.
P MarchesePediatric Neurology, Pediatric Department, Azienda Ospedaliera Universitaria Pisana, Via Roma 57, 56100, Pisa, Italy. marchese.pietro@yahoo.it.
A BonuccelliPediatric Neurology, Pediatric Department, Azienda Ospedaliera Universitaria Pisana, Via Roma 57, 56100, Pisa, Italy.
D G PeroniPediatric Neurology, Pediatric Department, Azienda Ospedaliera Universitaria Pisana, Via Roma 57, 56100, Pisa, Italy.
Azienda Ospedaliera Universitaria Pisana · IT

Funding

Università di Pisa 2017_38, DR n.83/2017
6 · The paper itself

Abstract

backgroundIn adult studies the MTHFR C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children.

methodsA retrospective study of children referred with headache to a tertiary level Paediatric Neurology Service between 2008 and 2012. This study included only patients who had been genotyped for the MTHFR C677T polymorphism. An evaluation of homocysteine serum levels was necessary to exclude other types of migraine.

conclusionCompared with the wild-type genotype, the T/T genotype was associated with an increased risk of any type of migraine, though the statistical significance was greatest in migraine with aura. The homocysteine serum levels were significantly higher in migraine with aura compared to migraine without aura. In a pediatric population MTHFR T/T homozygosity influences susceptibility to migraine.

Indexed as

Polymorphism, GeneticAdolescentAge DistributionAmbulatory CareChildChild, PreschoolCohort StudiesFemaleGenetic Predisposition to DiseaseGenotypeHomocysteineHumansIncidenceMaleMethylenetetrahydrofolate Reductase (NADPH2)Migraine DisordersHomocysteineMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanChildren migraineHyperhomocysteinemiaMigraineMigraine with auraMTHFRMTHFR C677T

Identifiers

PMID30170616
PMCPMC6119283
OpenAlexW2889428096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.