ArticleHealth and quality of life outcomes2018
Quality of life measures and health utility values among dry eye subgroups.
Article in Health and quality of life outcomes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review assessing the quality of patient reported outcomes measures in dry eye diseases.PloS one · 2021Pooled it
- Recombinant human nerve growth factor (cenegermin) for moderate-to-severe dry eye: phase II, randomized, vehicle-controlled, dose-ranging trial.BMC ophthalmology · 2024Trial
- Seasonal variations and environmental factors associated with allergic ocular surface disease: A prospective observational study of clinical presentation patterns in South Asian region.International ophthalmology · 2026Observational
- The Effect of Varenicline Nasal Spray on the Signs and Symptoms of Dry Eye Disease and Tear Film Stability: A Randomized Controlled Trial.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Dry Eye Disease: From Causes to Patient Care and Clinical Collaboration-A Narrative Review.Ophthalmology and therapy · 2025Review
- From Symptoms to Satisfaction: Optimizing Patient-Centered Care in Dry Eye Disease.Journal of clinical medicine · 2025Review
- The health-related quality of life in patients with dry eye syndrome: a cross-sectional study in Thailand.BMC ophthalmology · 2024Article
- Advancements in Hydrogels for Corneal Healing and Tissue Engineering.Gels (Basel, Switzerland) · 2024Review
- Optimal cutoff value of the dry eye-related quality-of-life score for diagnosing dry eye disease.Scientific reports · 2024Article
- Tear Fluid Biomarkers and Quality of Life in People with Type 2 Diabetes and Dry Eye Disease.Metabolites · 2023Article
- Rasch development and validation of the "Medellín Dry Eye Inventory" (ME·Dry), an instrument to measure multidimensional quality of life compromise in patients with dry eye disease.Indian journal of ophthalmology · 2023Article
- The Relationship between Subjective Symptoms and Quality of Life in Conjunctivochalasis Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Characteristics and Utility of Fluorescein Breakup Patterns among Dry Eyes in Clinic-Based Settings.Diagnostics (Basel, Switzerland) · 2020Article
- Loss of Concentration May Occur by Blink Inhibition in DED Simulation Models.Life (Basel, Switzerland) · 2020Article
- Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort.Cancer medicine · 2020Article
- Why the symptoms and objective signs of dry eye disease may not correlate.Journal of optometryReview
- Evaluation of lipid layer tear film changes after femtosecond small incision lenticule extraction.Therapeutic advances in ophthalmologyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine whether quality of life (QOL) and health utility are affected to the same extent among dry eye (DE) patients with short tear film break-up time dry eye (TBUT-DE) with minimal clinical signs were as severe as aqueous-deficient dry eye (ADDE).
methodsA multicenter cross-sectional study was conducted among DE patients who visited one of 10 eye clinics in Japan. Among the 463 registered patients, this study involved 449 patients with DE who were aged 20 years or older. Ophthalmic examination findings were assessed, including tear film break-up time (TBUT), Schirmer I value, and keratoconjunctival staining score. QOL was evaluated with the Dry Eye-Related Quality-of-Life Score (DEQS; 0 [best], 100 [worst]) and health utility (1 [total health], 0 [worst]) with the Health Utilities Index Mark 3 (HUI-3); scores were stratified by DE subgroup.
resultsMedian (interquartile range) of DEQS and HUI-3 scores across all participants were 21.7 (10.0-40.0) and 0.82 (0.69-0.91), respectively. Median (interquartile range) DEQS and HUI-3 scores in the ADDE group were 23.3 (10.0-40.0) and 0.79 (0.69-0.88), respectively; those in the short TBUT-DE group were 23.3 (13.3-38.3) and 0.82 (0.74-0.92), respectively. There were no significant between-group differences in questionnaire scores. Among the ophthalmic examination findings, a weak significant correlation between TBUT, corneal staining score and keratoconjunctival staining score to DEQS; TBUT and Schirmer test values to HUI-3, were seen.
conclusionsThe burden of short TBUT-DE on QOL as assessed by the DEQS and HUI-3 was as severe as that in ADDE. Our findings suggest that clinicians should be aware of the impact of short TBUT-DE on patients QOL and utility values.
trial registrationUniversity Hospital Medical Information Network (registration no. UMIN 000015890). Registered 10th December 2014, retrospectively registered.
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