ArticleBMC pulmonary medicine2018
Latent class analysis to define radiological subgroups in pulmonary nontuberculous mycobacterial disease.
Article in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Serum HMGB1 and CA19-9 are independently associated with pulmonary cavity formation in patients with non-tuberculous mycobacterial pulmonary disease.American journal of translational research · 2026Article
- LASSO regression-based nomogram for distinguishing nontuberculous mycobacterial pulmonary disease from pulmonary tuberculosis: a clinical risk prediction model.Scientific reports · 2025Article
- A practical guide to the diagnosis and management of suspected Non-tuberculous Mycobacterial Pulmonary Disease (NTM-PD) in the United Kingdom.NPJ primary care respiratory medicine · 2024Article
- Differential radiological features of patients infected or colonised with slow-growing non-tuberculous mycobacteria.Scientific reports · 2024Article
- Non-tuberculous mycobacterial pulmonary disease (NTM-PD): Epidemiology, diagnosis and multidisciplinary management.Clinical medicine (London, England) · 2024Review
- Differentiating nontuberculous mycobacterium pulmonary disease from pulmonary tuberculosis through the analysis of the cavity features in CT images using radiomics.BMC pulmonary medicine · 2022Article
- Non-tuberculous mycobacteria pulmonary disease: A review of trends, risk factors, diagnosis and management.African journal of thoracic and critical care medicine · 2022Review
- Relationship between clinical types and radiological subgroups defined by latent class analysis in 2019 novel coronavirus pneumonia caused by SARS-CoV-2.European radiology · 2020Article
- Article
- Prognostic nutritional index as a predictor of mortality in nontuberculous mycobacterial lung disease.Journal of thoracic disease · 2020Article
- Current and future management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the UK.BMJ open respiratory research · 2020Review
- Diagnosis of non-tuberculous mycobacterial pulmonary disease (NTM-PD): modern challenges.The British journal of radiology · 2020Article
- Non-tuberculous mycobacterial lung disease: a brief review focusing on radiological findings.Revista da Sociedade Brasileira de Medicina Tropical · 2020Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNontuberculous mycobacterial (NTM) pulmonary disease has conventionally been classified on the basis of radiology into fibrocavitary and nodular-bronchiectatic disease. Whilst being of great clinical utility, this may not capture the full spectrum of radiological appearances present. The aim of this study was to use latent class analysis (LCA) as an unbiased method of grouping subjects with NTM-pulmonary disease based on their CT features and to compare the clinical characteristics of these groups.
methodsIndividuals with NTM-pulmonary disease were recruited and a contemporaneous CT scan obtained. This was scored using an NTM-specific scoring system. LCA was used to identify groups with common radiological characteristics. The analysis was then repeated in an independent cohort.
resultsThree classes were identified in the initial cohort of 85 subjects. Group 1 was characterised by severe bronchiectasis, cavitation and aspergillomas, Group 2 by relatively minor radiological changes, and Group 3 by predominantly bronchiectasis only. These findings were reproduced in an independent cohort of 62 subjects. Subjects in Group 1 had a lower BMI and serum albumin, higher serum CRP, and a higher mortality.
conclusionsThese findings suggest that NTM-pulmonary may be divided into three radiological subgroups, and that important clinical and survival differences exist between these groups.
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