ArticleBMC pediatrics2018
Post hemorrhagic hydrocephalus and neurodevelopmental outcomes in a context of neonatal intraventricular hemorrhage: an institutional experience in 122 preterm children.
Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Neurodevelopmental outcomes in preterm or low birth weight infants with germinal matrix-intraventricular hemorrhage: a meta-analysis.Pediatric research · 2024Pooled it
- Pathophysiologic mechanisms and strategies for the treatment of post-hemorrhagic hydrocephalus of prematurity.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Pooled it
- Choroid plexus remodeling associated with inflammatory CSF exposure in preterm acquired hydrocephalus.iScience · 2026Article
- Factors associated with ventriculoperitoneal shunt conversion and intraparenchymal hemorrhage following ventriculosubgaleal shunt for post-hemorrhagic ventricular dilatation.Pediatric research · 2026Article
- Exploring hemoglobin dynamics and scavenging mechanisms in preterm infants and preterm rabbits with cerebral intraventricular hemorrhage.Pediatric research · 2026Article
- Exposure to enriched environment and parental care ameliorates brain pathology and behavioral impairment after germinal-matrix intraventricular hemorrhage.Molecular psychiatry · 2026Article
- End-of-life circumstances and unanticipated deaths in a neonatal intensive care unit: a retrospective analysis.BMC palliative care · 2026Article
- The significance and utility of ventricular access devices in children with proximal CSF shunt malfunction.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Neurodevelopmental outcome of perinatal intracranial haemorrhage in patients born at term: A prospective study.Developmental medicine and child neurology · 2025Observational
- Ventricular Subgaleal Shunt in Children Under Three Months of Age, from Diagnosis to Outcome: A Review After 11 Years of Experience in a French University Hospital.Children (Basel, Switzerland) · 2025Article
- Article
- Association of germinal matrix hemorrhage volume with neurodevelopment and hydrocephalus.Journal of neurosurgery. Pediatrics · 2024Article
- Could we detect intraventricular hemorrhage before it happens?Pediatric research · 2024Article
- Long-term outcomes of very low birth weight infants with intraventricular hemorrhage: a nationwide population study from 2011 to 2019.World journal of pediatrics : WJP · 2024Article
- Current Status and Associated Factors of Post-Hemorrhagic Hydrocephalus in Infants of 22 to 28 Weeks Gestation With Severe Intraventricular Hemorrhage in Korea: A Nationwide Cohort Study.Journal of Korean medical science · 2024Article
- Role of N-formyl peptide receptor 2 in germinal matrix hemorrhage: an intrinsic review of a hematoma resolving pathway.Neural regeneration research · 2024Review
- The Frequency of Intraventricular Hemorrhage and its Risk Factors.Current pediatric reviews · 2024Article
- Evaluation of recombinant human IGF-1/IGFBP-3 on intraventricular hemorrhage prevention and survival in the preterm rabbit pup model.Scientific reports · 2023Article
- Progress in Research on Stem Cells in Neonatal Refractory Diseases.Journal of personalized medicine · 2023Review
- Neurodevelopmental outcomes of neonatal posthemorrhagic hydrocephalus and psychological effects on the parents.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraventricular hemorrhage (IVH) is a frequent complication in extreme and very preterm births. Despite a high risk of death and impaired neurodevelopment, the precise prognosis of infants with IVH remains unclear. The objective of this study was to evaluate the rate and predictive factors of evolution to post hemorrhagic hydrocephalus (PHH) requiring a shunt, in newborns with IVH and to report their neurodevelopmental outcomes at 2 years of age.
methodsAmong all preterm newborns admitted to the department of neonatalogy at Rouen University Hospital, France between January 2000 and December 2013, 122 had an IVH and were included in the study. Newborns with grade 1 IVH according to the Papile classification were excluded.
resultsAt 2-year, 18% (n = 22) of our IVH cohort required permanent cerebro spinal fluid (CSF) derivation. High IVH grade, low gestational age at birth and increased head circumference were risk factors for PHH. The rate of death of IVH was 36.9% (n = 45). The rate of cerebral palsy was 55.9% (n = 43) in the 77 surviving patients (49.4%). Risk factors for impaired neurodevelopment were high grade IVH and increased head circumference.
conclusionHigh IVH grade was strongly correlated with death and neurodevelopmental outcome. The impact of an increased head circumference highlights the need for early management. CSF biomarkers and new medical treatments such as antenatal magnesium sulfate have emerged and could predict and improve the prognosis of these newborns with PHH.
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