ArticleBMC genomics2018
Attack of the clones: whole genome-based characterization of two closely related enterohemorrhagic Escherichia coli O26 epidemic lineages.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Pathogenic potential and phylogenomic analysis ofMicrobial genomics · 2026Article
- Phylogenetic relationship and virulence composition ofFrontiers in microbiology · 2023Article
- Population Analysis of O26 Shiga Toxin-ProducingFrontiers in cellular and infection microbiology · 2022Article
- The population genetics of pathogenic Escherichia coli.Nature reviews. Microbiology · 2021Review
- Strain-Level Metagenomic Data Analysis of Enriched In Vitro and In Silico Spiked Food Samples: Paving the Way towards a Culture-Free Foodborne Outbreak Investigation Using STEC as a Case Study.International journal of molecular sciences · 2020Article
- Virulence Profiling and Molecular Typing of Shiga Toxin-ProducingMicroorganisms · 2020Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundEnterohemorrhagic Escherichia coli (EHEC) O26:H11/H
resultsGenome-wide single nucleotide polymorphism (SNP)-based analysis of 32 EHEC O26 isolated in the Czech Republic, Germany, Austria and Italy demonstrated a split of the nEC (ST29C2 clonal group) into two distinct lineages, which we termed, based on their temporal emergence, as "early" nEC and "late" nEC. The evolutionary divergence of the early nEC and late nEC is marked by the presence of 59 and 70 lineage-specific SNPs (synapomorphic mutations) in the genomes of the respective lineages. In silico analyses of publicly available E. coli O26 genomic sequences identified the late nEC lineage worldwide. Using a PCR designed to target the late nEC synapomorphic mutation in the sen/ent gene, we identified the early nEC decline accompanied by the late nEC rise in Germany and the Czech Republic since 2004 and 2013, respectively. Most of the late nEC strains harbor one of two major types of Shiga toxin 2a (Stx2a)-encoding prophages. The type I stx
conclusionsUsing SNP-level analyses, we provide the evidence of the evolutionary split of EHEC O26:H11/H
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