Observational studyMedicine2018
Analysis of trends in usage of analgesics and sedatives in intensive care units of South Korea: A retrospective nationwide population-based study.
Observational study in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Characteristics and management of mechanically ventilated patients in South Korea compared with other high-income Asian countries and regions.Acute and critical care · 2025Article
- Trends in hospital admission related to poisoning by, narcotics and psychodysleptics and poisoning by antiepileptic, sedative-hypnotic, and antiparkinsonism drugs in England and Wales between April 1999 and April 2020: An ecological study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Sedative polypharmacy mediates the effect of mechanical ventilation on delirium in critically ill COVID-19 patients: A retrospective cohort study.Acta anaesthesiologica Scandinavica · 2022Article
- Change in management and outcome of mechanical ventilation in Korea: a prospective observational study.The Korean journal of internal medicine · 2022Observational
- Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours.Journal of Korean medical science · 2021Article
- Comparative Safety Profiles of Sedatives Commonly Used in Clinical Practice: A 10-Year Nationwide Pharmacovigilance Study in Korea.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Remifentanil provides an increased proportion of time under light sedation than fentanyl when combined with dexmedetomidine for mechanical ventilation.The Journal of international medical research · 2021Article
- Stroke Incidence in Survivors of Carbon Monoxide Poisoning in South Korea: A Population-Based Longitudinal Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of analgesics and sedatives plays an important role in improving patient outcomes in the intensive care unit (ICU). Various drugs exist, each with associated differences in patient outcomes; therefore, critical and intensive care medicine societies have developed guidelines for usage of analgesics and sedatives for improved patient outcomes. However, studies investigating drug use in the ICU have been based on surveys administered to medical staff, without accurate insight into the drug use based on prescriptions and behaviors of ICU medical staff, thus failing to demonstrate the actual status of the implementation of these guidelines into clinical practice. Using data from the Health Insurance Review and Assessment Service in South Korea, we analyzed the current use of analgesics and sedatives in ICUs nationally. In addition, we compared the use of analgesics and sedatives in the ICU based on the latest guidelines.We performed a nationwide retrospective study using data available in the Health Insurance Review and Assessment Service database. We included 779,985 patients who had been admitted to the ICU from January 1, 2010, to December 31, 2014. Descriptive statistics were calculated to analyze the type and frequency of analgesic and sedative use in the ICU, using drug codes for analgesics and sedatives commonly prescribed in the ICU.The most commonly used analgesics and sedatives for all patients admitted to the ICU were pethidine (26.14%) and midazolam (32.18%), respectively. Sedatives and analgesics were more commonly used in mechanically ventilated patients. Among analgesics, the usage rate of pethidine and morphine decreased, whereas the usage rate of fentanyl and remifentanil increased. Among sedatives, the usage rate of benzodiazepine decreased, whereas the usage rate of propofol increased.There was discordance between current usage of analgesics and sedatives and the recommended usage stipulated by ICU guidelines. However, the trend of drug usage is changing to match the guidelines, which recommend maintenance of light sedation using an analgesia-based regimen and usage of short-acting drugs for routine monitoring of pain, agitation, and delirium in ICU care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.