SynthesisMedicine2018
Non-alcoholic fatty liver disease and the risk of urolithiasis: A systematic review and meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Association between metabolic dysfunction-associated steatotic liver disease and risk of urolithiasis: an updated systematic review and meta-analysis.Internal and emergency medicine · 2024Pooled it
- Trial
- ZJU index and prevalence of kidney stones in US adults: evidence for a threshold association from NHANES 2007-2018.Translational andrology and urology · 2026Article
- ZJU index and the prevalence of kidney stones in US adults: evidence from NHANES 2007-2018.BMC urology · 2026Article
- Association between metabolic dysfunction-associated steatotic liver disease and kidney stone risk in individuals with metabolic dysfunction: evidence from cross-sectional and cohort analyses.Frontiers in endocrinology · 2026Article
- Association of Kidney Stone Disease With Metabolic Dysfunction Associated Liver Disease and Metabolic Dysfunction Associated Steatohepatitis: A National Inpatient Sample Study.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Factors Influencing Oxalate Synthesis in Healthy Volunteers.Journal of endourology · 2025Article
- Metabolic dysfunction associated steatotic liver and kidney stones: what is going on?Current opinion in nephrology and hypertension · 2025Review
- Metabolic dysfunction-associated fatty liver disease as a mediator of urolithiasis risk: evidence from cross-sectional and genetic studies.International journal of medical sciences · 2025Article
- Metabolic dysfunction-associated fatty liver disease and risk of nephrolithiasis: a sizeable cross-sectional study.Frontiers in endocrinology · 2024Article
- Hepatic PTP4A1 ameliorates high-fat diet-induced hepatosteatosis and hyperglycemia by the activation of the CREBH/FGF21 axis.Theranostics · 2023Article
- A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones.Frontiers in endocrinology · 2023Article
- Non-alcoholic Fatty Liver Disease and Steatohepatitis: Risk Factors and Pathophysiology.Middle East journal of digestive diseases · 2022Review
- Molecular and pathobiological involvement of fetuin-A in the pathogenesis of NAFLD.Inflammopharmacology · 2021Review
- NAFLD and Infection, a Nuanced Relationship.Canadian journal of gastroenterology & hepatology · 2021Review
- Relationship Between Urolithiasis and Fatty Liver Disease: Findings in Computed Tomography.Tomography (Ann Arbor, Mich.) · 2020Article
- Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal-Regulating Kinase 1 Pathways.Hepatology (Baltimore, Md.) · 2019Article
- Article
- The grade of nonalcoholic fatty liver disease is an independent risk factor for gallstone disease: An observational Study.Medicine · 2019Observational
- Hepatic, Extra-hepatic Outcomes and Causes of Mortality in NAFLD - An Umbrella Overview of Systematic Review of Meta-Analysis.Journal of clinical and experimental hepatologyReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing evidence that nonalcoholic fatty liver disease (NAFLD) is associated with a higher risk of urolithiasis, but it has not yet been determined that this association is reproducible and consistent across different studies. We performed a systematic review and meta-analysis of these studies to examine the association between NAFLD and the risk of urolithiasis.We searched PubMed, EMBASE, and Google scholar using terms "fatty liver" (OR "non-alcoholic fatty liver disease" OR "non-alcoholic steatohepatitis" OR "NAFLD" OR "NASH") AND "urolithiasis" (OR "nephrolithiasis" OR "kidney stone" OR "urinary calculi" OR "renal colic" OR "urologic disease"). Observational studies in which NAFLD and urolithiasis were diagnosed by either ultrasonography or computerized tomography were included.A total of 7 observational studies with 226,541 individuals (24.7% with NAFLD) and 19,184 urolithiasis (8.5%). NAFLD was significantly associated with an increased risk of urolithiasis (random effect odds ratio, OR 1.73, 95% confidence interval, CI 1.24-2.40, I=94.5%). Sensitivity analyses revealed the robustness of the results. Egger test and Begg test suggested no publication bias (P > .05).NAFLD is associated with an increased risk of urolithiasis. Therefore, patients with NAFLD should be carefully monitored for the development of urolithiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.