ArticleJournal of affective disorders2019
Divergent associations between ghrelin and neural responsivity to palatable food in hyperphagic and hypophagic depression.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Investigating functional connectivity differences during food vs. monetary reward processing across appetitive phenotypes of major depressive disorder.Journal of affective disorders · 2026Article
- Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin.International journal of molecular sciences · 2025Review
- Ghrelin in Depression: A Promising Therapeutic Target.Molecular neurobiology · 2025Review
- Divergent transcriptomic profiles in depressed individuals with hyper- and hypophagia implicating inflammatory status.Journal of psychiatric research · 2024Article
- The Contribution of the Brain-Gut Axis to the Human Reward System.Biomedicines · 2024Review
- Mechanisms Involved in the Link between Depression, Antidepressant Treatment, and Associated Weight Change.International journal of molecular sciences · 2024Review
- Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights.Physiology & behavior · 2023Review
- The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium.The American journal of clinical nutrition · 2023Article
- Alterations in resting-state functional activity and connectivity for major depressive disorder appetite and weight disturbance phenotypes.Psychological medicine · 2023Article
- Sugars and Sweet Taste: Addictive or Rewarding?International journal of environmental research and public health · 2021Review
- The Relationship Between Food Craving, Appetite-Related Hormones and Clinical Parameters in Bipolar Disorder.Nutrients · 2020Article
- The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders.Frontiers in synaptic neuroscience · 2020Review
- Appetite change profiles in depression exhibit differential relationships between systemic inflammation and activity in reward and interoceptive neurocircuitry.Brain, behavior, and immunity · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe neurobiological mechanisms involved in divergent appetitive phenotypes in major depressive disorder (MDD) are not well understood, although recent data suggest disruption in mesolimbic reward circuitry. Ghrelin, an orexigenic hormone, has been shown to modulate the reward circuitry. We aimed to investigate the relationship between acylated ghrelin levels and the neural response to food stimuli in individuals with hyperphagic and hypophagic MDD in remission.
methodsWomen with hyperphagic MDD (n = 10), hypophagic MDD (n = 18), and healthy controls (HC; n = 18) underwent fMRI scanning during which they viewed images of food. The fMRI session was followed by a standardized meal, appetite ratings, and serial blood draws.
resultsIn individuals with hyperphagic MDD, greater change in acylated ghrelin in response to a meal was associated with increased BOLD response to high-calorie food in the bilateral ventral tegmental area and left hypothalamus. In contrast, negative associations were observed between acylated ghrelin AUC and BOLD activity in the right hypothalamus in the hypophagic MDD group. LIMITATIONS: Unbalanced group sizes with a relatively small sample in the hyperphagic MDD group.
conclusionsIn the absence of differences in absolute ghrelin levels between the hyperphagic MDD and HC groups, results in hyperphagic MDD might suggest a ghrelinergic signaling mechanism for increased appetite during an MDD episode in this group. Our findings shed light on interactions between appetite hormones and mesolimbic circuitry which could contribute to development of therapeutic targets for opposing appetite phenotypes in depression.
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