ReviewHeart rhythm2019
Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms.
Review in Heart rhythm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04284150 (Treatment of Supraventricular Tachycardia in Patients With Non-cardiac Surgery by Dexmedetomidine During the Perioperative Period), which is not on this map. Cited by 102 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Supraventricular Tachycardia in Patients With Non-cardiac Surgery by Dexmedetomidine During the Perioperative Period
Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychotic relapse prediction via biomarker monitoring: a systematic review.Frontiers in psychiatry · 2024Pooled it
- Exercise modality but not hypoxia alters heart rate variability after a single repeated-sprint session.European journal of applied physiology · 2026Trial
- Effect of olfactory stimulation from aromatherapy on the autonomic nervous activity during aerobic exercises.Scientific reports · 2024Trial
- Effects of Caffeine Intake on Cardiopulmonary Variables and QT Interval after a Moderate-Intensity Aerobic Exercise in Healthy Adults: A Randomized Controlled Trial.BioMed research international · 2022Trial
- The nutritional and metabolic impact of night shift work in a real-world setting.Npj biological timing and sleep · 2026Article
- Circadian chaos of ventricular tachyarrhythmia: a novel digital phenotype predicts mortality in high-risk SCD patients.Journal of geriatric cardiology : JGC · 2026Article
- Circadian regulation of cardiovascular function: from physiology to clinical implications.Genome medicine · 2026Review
- Obstructive Sleep Apnea and Arrhythmia: A Narrative Review of Arrhythmogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2026Review
- Community-acquired pneumonia alters circadian regulation of cardiac electrophysiology in children.European journal of pediatrics · 2026Article
- The interactive effect of long nighttime sleep and daytime napping on QTc prolongation in hypertensive adults.BMC cardiovascular disorders · 2026Article
- Neural Regulation of Cardiac Arrhythmias: From the Brain-Heart Axis to Emerging Precision Therapies.Research (Washington, D.C.) · 2026Review
- Circadian variation of post-operative complications in lung resection surgery.Frontiers in physiology · 2026Article
- Neurobiology of the circadian clock and its role in cardiovascular disease: Mechanisms, biomarkers, and chronotherapy.Neurobiology of sleep and circadian rhythms · 2025Review
- Age and sex affect circadian patterns of cardiac autonomic function.Scientific reports · 2025Article
- Assessment of Sleep-wake State-associated Dynamic Changes in Heart Rate Variability in Female Rat: Autonomic System Modelling Approaches for Studying Behavioural Dysregulation.Annals of neurosciences · 2025Article
- Autonomic biosignals, seizure detection, and forecasting.Epilepsia · 2025Review
- Circadian Rhythm Disruptions and Cardiovascular Disease Risk: The Special Role of Melatonin.Current issues in molecular biology · 2025Review
- Biorhythms derived from consumer wearables predict postoperative complications in children.Science advances · 2025Article
- Cardiogenic and chronobiological mechanisms in seizure-induced sinus arrhythmias.PLoS computational biology · 2025Article
- BMAL1 in Ischemic Heart Disease: A Narrative Review from Molecular Clock to Myocardial Pathology.International journal of molecular sciences · 2025Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Cardiac arrhythmias are a leading cause of cardiovascular death. It has long been accepted that life-threatening cardiac arrhythmias (ventricular tachycardia, ventricular fibrillation, and sudden cardiac death) are more likely to occur in the morning after waking. It is perhaps less well recognized that there is a circadian rhythm in cardiac pacemaking and other electrophysiological properties of the heart. In addition, there is a circadian rhythm in other arrhythmias, for example, bradyarrhythmias and supraventricular arrhythmias. Two mechanisms may underlie this finding: (1) a central circadian clock in the suprachiasmatic nucleus in the hypothalamus may directly affect the electrophysiology of the heart and arrhythmogenesis via various neurohumoral factors, particularly the autonomic nervous system; or (2) a local circadian clock in the heart itself (albeit under the control of the central clock) may drive a circadian rhythm in the expression of ion channels in the heart, which in turn varies arrhythmic substrate. This review summarizes the current understanding of the circadian rhythm in cardiac electrophysiology, arrhythmogenesis, and the underlying molecular mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.