Evidence map›Paper›PMID 30170218›Full record

SynthesisAtherosclerosis2018

Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions.

Jacob L Barber, William E Kraus, Timothy S Church, James M Hagberg, Paul D Thompson, David B Bartlett, Michael W Beets, Conrad P Earnest, Kim M Huffman, Rian Q Landers-Ramos and 8 more

Abstract readComparative StudyMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Atherosclerosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Title: Human Serum/Plasma Glycoprotein Analysis byJournal of clinical medicine · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jacob L BarberDepartment of Exercise Science, University of South Carolina, Columbia, SC, USA.
William E KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Timothy S ChurchPennington Biomedical Research Center, Baton Rouge, LA, USA.
James M HagbergDepartment of Kinesiology, University of Maryland, College Park, MD, USA.
Paul D ThompsonCardiology Division, Hartford Hospital, Hartford, CT, USA.
David B BartlettDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Michael W BeetsDepartment of Exercise Science, University of South Carolina, Columbia, SC, USA.
Conrad P EarnestDepartment of Health & Kinesiology, Texas A&M University, College Station, TX, USA.
Kim M HuffmanDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Rian Q Landers-RamosDepartment of Kinesiology, University of Maryland, College Park, MD, USA.
Arthur S LeonSchool of Kinesiology, University of Minnesota, Minneapolis, MN, USA.
D C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Richard L SeipCardiology Division, Hartford Hospital, Hartford, CT, USA.
James S SkinnerProfessor Emeritus of Kinesiology, Indiana University, Bloomington, IN, USA.
Cris A SlentzDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Kenneth R WilundDepartment of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, IL, USA.
Claude BouchardPennington Biomedical Research Center, Baton Rouge, LA, USA.
Mark A SarzynskiDepartment of Exercise Science, University of South Carolina, Columbia, SC, USA. Electronic address: sarz@mailbox.sc.edu.

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1M
Mentoring Obesity and Diabetes Research in LouisianaP20GM103528 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2012 to 2015
$8.8M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL045670 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RANKINEN, TUOMO · 1992 to 2010
$6.8M
Transgenics CoreP30GM118430 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MYNATT, RANDALL LEE · 2016 to 2020
$5.8M
PERIPHERAL EFFECTS OF EXERCISE ON CARDIOVASCULAR HEALTHR01HL057354 · NHLBI · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 1998 to 2008
$5.5M
DOSE-RESPONSE TO EXERCISE IN WOMEN AGED 45-75 YEARSR01HL066262 · NHLBI · COOPER INSTITUTE · PI BLAIR, STEVEN N. · 2001 to 2005
$3.6M
Exercise Dose-Response Effects in Prediabetes:Responses and MechanismsR01DK081559 · NIDDK · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 2009 to 2013
$3.1M
ACE GENOTYPE, BP, AND EXERCISE TRAINING IN HYPERTENSIVESR01AG017474 · NIA · UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS · PI HAGBERG, JAMES M · 2000 to 2004
$2.1M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047317 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 1992 to 2003
$1.8M
APO E GENOTYPE AND HDL CHANGES WITH EXERCISE TRAININGR01AG015389 · NIA · UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS · PI HAGBERG, JAMES M · 1998 to 2002
$1.1M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047327 · NHLBI · INDIANA UNIVERSITY BLOOMINGTON · PI SKINNER, JAMES STANFORD · 1992 to 2003
$106k
HERITAGE STUDY: GENETICS, RESP. TO EXERCISE/RISK FACTORSR01HL047323 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LEON, ARTHUR S · 1992 to 2003
$100k
NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL047317NHLBI NIH HHS R01 HL047323NHLBI NIH HHS R01 HL047327NHLBI NIH HHS R01 HL057354NHLBI NIH HHS R01 HL066262NIA NIH HHS R01 AG015389NIA NIH HHS R01 AG017474NIDDK NIH HHS R01 DK081559NIGMS NIH HHS P20 GM103528NIGMS NIH HHS P30 GM118430NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

BACKGROUND AND

aimsGlycA is a relatively new biomarker for inflammation as well as cardiometabolic disease risk. However, the effect of exercise on GlycA is largely unknown. Therefore, the purpose of this study was to examine the effects of regular exercise on the inflammatory marker GlycA across seven studies and 14 exercise interventions.

methodsNuclear magnetic resonance spectroscopy, specifically signal amplitudes originating from the N-acetyl methyl group protons of the N-acetylglucosamine residues on the glycan branches of glycoproteins, was used to quantify GlycA concentrations. GlycA was measured before and after completion of an exercise intervention in 1568 individuals across seven studies and 14 exercise interventions. Random effects inverse variance weighting models were used to pool effects across interventions.

resultsCombined analysis of unadjusted data showed that regular exercise significantly (p = 2 × 10

conclusionsRegular exercise significantly reduced plasma GlycA across 14 different exercise interventions despite differences in exercise programs and study populations. The current study provides a greater understanding of the use of exercise as a potential therapy for the reduction of systemic inflammation. Further research is needed to understand the mechanisms behind the exercise-related reductions in GlycA.

Indexed as

ExercisePhysical EnduranceAdultAgedBiomarkersDown-RegulationExercise TherapyFemaleGlycated HemoglobinHumansInflammation MediatorsMagnetic Resonance SpectroscopyMaleMiddle AgedTime FactorsYoung AdultBiomarkersGlycated HemoglobinInflammation MediatorsExercise trainingInflammationNMR spectroscopy

Identifiers

PMID30170218
PMCPMC6298739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.