Evidence map›Paper›PMID 30170082›Full record

ArticleNeuropharmacology2018

Evidence for intact 5-HT

Jessica A Babb, Sofia E Linnros, Kathryn G Commons

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Beyond the 5-HTThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  2. Article
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jessica A BabbDepartment of Anesthesiology, Perioperative, and Pain Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA; Department of Anesthesia, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA. Electronic address: jessica.babb@colorado.edu.
Sofia E LinnrosDepartment of Anesthesiology, Perioperative, and Pain Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA; Department of Pharmaceutical Biosciences, Uppsala University, 751 05 Uppsala, Sweden. Electronic address: sofia.linnros@gmail.com.
Kathryn G CommonsDepartment of Anesthesiology, Perioperative, and Pain Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA; Department of Anesthesia, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA. Electronic address: kathryn.commons@childrens.harvard.edu.
Boston Children's Hospital · USUppsala University · SE

Funding

VENTRAL MEDULLA, BREATHING, AND CENTRAL CHEMORECEPTIONP01HD036379 · NICHD · HARVARD MEDICAL SCHOOL · PI DYMECKI, SUSAN M. · 1998 to 2017
$32.2M
Topography of Serotonin DysfunctionR01DA021801 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI COMMONS, KATHRYN G · 2007 to 2018
$3.6M
Serotonin, hippocampal theta, and copingF32MH108247 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI BABB, JESSICA A · 2015 to 2017
$182k
NICHD NIH HHS P01 HD036379NIDA NIH HHS R01 DA021801NIMH NIH HHS F32 MH108247
6 · The paper itself

Abstract

Serotonin (5-HT) neurons are strongly implicated in mood disorders such as depression and are importantly regulated by feedback inhibition mediated by 5-HT

Indexed as

Maternal DeprivationAnimalsDorsal Raphe NucleusFeedback, PhysiologicalFluoxetineMalePiperazinesProto-Oncogene Proteins c-fosPyridinesRatsReceptor, Serotonin, 5-HT1ASerotonergic NeuronsSerotonin 5-HT1 Receptor AntagonistsFluoxetineN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidePiperazinesProto-Oncogene Proteins c-fosPyridinesReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AntagonistsFluoxetineFluoxetine hydrochloride (PubChem CID: 62857)FosRapheSerotoninStressSwimWAY-100635 (PubChem CID: 5684)

Identifiers

PMID30170082
PMCPMC6170686
OpenAlexW2889052423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.