ArticlePlant & cell physiology2019
Agrobacterium tumefaciens Enhances Biosynthesis of Two Distinct Auxins in the Formation of Crown Galls.
Article in Plant & cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 64 citations in OpenAlex.
- A probabilistic approach for predicting indole-3-acetic acid synthesis in bacteria using genomic data.BMC bioinformatics · 2026Article
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- Auxin dysregulation: a key early event in sugarcane susceptibility to Sporisorium scitamineum.BMC plant biology · 2026Article
- Extended phenotype of phytoplasmas in eukaryotic systems: mechanisms and ecological implications.Frontiers in plant science · 2026Review
- Mutual inhibition between EPFL2 and auxin extends the intervals of periodic leaf morphogenesis.Nature communications · 2025Article
- Microbial drivers of root plasticity.The New phytologist · 2025Review
- Co-transformation using T-DNA genes from Agrobacterium strain 82.139 enhances regeneration of transgenic shoots in Populus.Plant biotechnology journal · 2025Article
- Indole Acetic Acid: A Key Metabolite That Protects MarineMicroorganisms · 2025Article
- Engineering Agrobacterium for improved plant transformation.The Plant journal : for cell and molecular biology · 2025Review
- The Roles of GRETCHEN HAGEN3 (GH3)-Dependent Auxin Conjugation in the Regulation of Plant Development and Stress Adaptation.Plants (Basel, Switzerland) · 2023Review
- Hormonal Interplay Leading to Black Knot Disease Establishment and Progression in Plums.Plants (Basel, Switzerland) · 2023Article
- Biosynthetic Pathways and Functions of Indole-3-Acetic Acid in Microorganisms.Microorganisms · 2023Review
- Occurrence, Function, and Biosynthesis of the Natural Auxin Phenylacetic Acid (PAA) in Plants.Plants (Basel, Switzerland) · 2023Review
- Inactivation of tomatoFrontiers in plant science · 2023Article
- Identification and combinatorial engineering of indole-3-acetic acid synthetic pathways in Paenibacillus polymyxa.Biotechnology for biofuels and bioproducts · 2022Article
- Enhancement of shoot regeneration by treatment with inhibitors of auxin biosynthesis and transport during callus induction in tissue culture ofPlant biotechnology (Tokyo, Japan) · 2022Article
- Plant susceptible responses: the underestimated side of plant-pathogen interactions.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Phenotype Switching in Metal-Tolerant Bacteria Isolated from a Hyperaccumulator Plant.Biology · 2021Article
- Auxin Plays Multiple Roles during Plant-Pathogen Interactions.Cold Spring Harbor perspectives in biology · 2021Review
- Molecular and Histologic Adaptation of Horned Gall Induced by the AphidInternational journal of molecular sciences · 2021Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
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Abstract
The plant pathogen Agrobacterium tumefaciens infects plants and introduces the transferred-DNA (T-DNA) region of the Ti-plasmid into nuclear DNA of host plants to induce the formation of tumors (crown galls). The T-DNA region carries iaaM and iaaH genes for synthesis of the plant hormone auxin, indole-3-acetic acid (IAA). It has been demonstrated that the iaaM gene encodes a tryptophan 2-monooxygenase which catalyzes the conversion of tryptophan to indole-3-acetamide (IAM), and the iaaH gene encodes an amidase for subsequent conversion of IAM to IAA. In this article, we demonstrate that A. tumefaciens enhances the production of both IAA and phenylacetic acid (PAA), another auxin which does not show polar transport characteristics, in the formation of crown galls. Using liquid chromatography-tandem mass spectroscopy, we found that the endogenous levels of phenylacetamide (PAM) and PAA metabolites, as well as IAM and IAA metabolites, are remarkably increased in crown galls formed on the stem of tomato plants, implying that two distinct auxins are simultaneously synthesized via the IaaM-IaaH pathway. Moreover, we found that the induction of the iaaM gene dramatically elevated the levels of PAM, PAA and its metabolites, along with IAM, IAA and its metabolites, in Arabidopsis and barley. From these results, we conclude that A. tumefaciens enhances biosynthesis of two distinct auxins in the formation of crown galls.
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