ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020
Kidney size in relation to ageing, gender, renal function, birthweight and chronic kidney disease risk factors in a general population.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Sex and Gender Differences in Chronic Kidney Disease-Explained by the Brenner-Luyckx Concept of Hyperfiltration.Journal of clinical medicine · 2026Review
- Doppler ultrasound for the evaluation of chronic renal allograft dysfunction.Quantitative imaging in medicine and surgery · 2026Article
- Observational
- Imaging and spatially resolved mass spectrometry applications in nephrology.Nature reviews. Nephrology · 2025Review
- Effect of retention time on renal function and kidney size in patients with indwelling DJ tubes.Scientific reports · 2025Article
- Renal functional reserve in living kidney donors.Clinical kidney journal · 2025Article
- How histopathological diagnosis interacts with kidney ultrasound parameters and glomerular filtration rate.Internal and emergency medicine · 2024Article
- Kidney Volume and Risk of Incident Kidney Outcomes.Journal of the American Society of Nephrology : JASN · 2024Article
- A Triple Mystery of Insidious Organ Failure: Are the Lung, Kidney and Brain All Damaged by the Ageing Pulse?Biomedicines · 2024Review
- A Pilot Comparative Study between Creatinine- and Cystatin-C-Based Equations to Estimate GFR and Kidney Ultrasound Percentiles in Children with Congenital Anomalies of the Kidney and Urinary Tract.Diagnostics (Basel, Switzerland) · 2024Article
- Associations of MRI-derived kidney volume, kidney function, body composition and physical performance in ≈38 000 UK Biobank participants: a population-based observational study.Clinical kidney journal · 2024Article
- Exploring the link between kidney dimensions and anthropometric measurements: insights from a Saudi population study.Archives of medical sciences. Atherosclerotic diseases · 2024Article
- Kidney shape statistical analysis: associations with disease and anthropometric factors.BMC nephrology · 2023Article
- Magnesium in Kidney Function and Disease-Implications for Aging and Sex-A Narrative Review.Nutrients · 2023Review
- Ultrasonography Measurement of Renal Dimension and Its Correlation with Age, Body Indices, and eGFR in Type 1 Diabetes Mellitus Patients: Real World Data in Taiwan.Journal of clinical medicine · 2023Article
- Ultrasound Renal Score to Predict the Renal Disease Prognosis in Patients with Diabetic Kidney Disease: An Investigative Study.Diagnostics (Basel, Switzerland) · 2023Article
- The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Observational
- Birth Weight Is Associated With Kidney Size in Middle-Aged Women.Kidney international reports · 2021Article
- Cardiorenal Syndrome: Emerging Role of Medical Imaging for Clinical Diagnosis and Management.Journal of personalized medicine · 2021Review
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Authors and funding
20 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundThe relationship of kidney size to ageing, kidney function and kidney disease risk factors is not fully understood.
methodsUltrasound length and parenchymal kidney volume were determined from a population-based sample of 3972 Sardinians (age range 18-100 years). We then identified the subset of 2256 'healthy' subjects to define age- and sex-specific reference ranges (2.5-97.5 percentile) of kidney volume. Logistic regression (accounting for family clustering) was used to identify the clinical characteristics associated with abnormally large kidneys or abnormally small kidneys.
resultsIn the healthy subset, kidney volume and length increased up to the fourth to fifth decade of life followed by a progressive decrease in men, whereas there was a gradual kidney volume decrease throughout the lifespan of women. In the whole sample, independent predictors of lower kidney volume (<2.5 percentile for age and sex) were male sex, low body mass index, short height, low waist:hip ratio and high serum creatinine (SCr); the independent predictors of larger kidney volume (>97.5 percentile for age and sex) were younger age, female sex, diabetes, obesity, high height, high waist:hip ratio and lower SCr. Estimated heritability for kidney volume was 15%, and for length 27%; kidney volume correlated strongly with birthweight.
conclusionsOverall, in a general healthy population, kidney measures declined with age differently in men and women. The determinants of kidney parenchymal volume include genetic factors and modifiable clinical factors.
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