Evidence map›Paper›PMID 30169657›Full record

SynthesisEuropean heart journal2018

A comprehensive evaluation of the genetic architecture of sudden cardiac arrest.

Foram N Ashar, Rebecca N Mitchell, Christine M Albert, Christopher Newton-Cheh, Jennifer A Brody, Martina Müller-Nurasyid, Anna Moes, Thomas Meitinger, Angel Mak, Heikki Huikuri and 54 more

Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European heart journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00604149 (Etude Multicentrique en Population de la susceptibilité génétique à Faire Une Mort Subite), which is not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00604149 completednot on this map

Etude Multicentrique en Population de la susceptibilité génétique à Faire Une Mort Subite

TypeobservationalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2008 to 2014Enrolled2,332ConditionsOut-of-hospital Cardiac Arrest
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Trial
  5. Article
  6. Review
  7. Observational
  8. Review
  9. Impact of Sorbs2 dysfunction on cardiovascular diseases.Biochimica et biophysica acta. Molecular basis of disease · 2025
    Review
  10. Article
  11. Baseline and 10-year change in the number of ideal cardiovascular health metrics and sudden cardiac death in the community.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Risk stratification of sudden cardiac death: a review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

64 authors at 20 institutions in 11 countries.

Foram N AsharMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins, 733 N Broadway, Baltimore, MD, USA.
Rebecca N MitchellMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins, 733 N Broadway, Baltimore, MD, USA.
Christine M AlbertDivisions of Preventive Medicine and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave East, 3rd Floor, Boston, MA, USA.
Christopher Newton-ChehCenter for Human Genetic Research & Cardiovascular Research Center, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, 1730 Minor Ave, Seattle, WA, USA.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany.
Anna MoesMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins, 733 N Broadway, Baltimore, MD, USA.
Thomas MeitingerDZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Biedersteiner Strasse 29, Munich, Germany.
Angel MakCardiovascular Research Institute and Institute for Human Genetics, University of California, San Francisco, 1550 4th Street, San Francisco, CA, USA.
Heikki HuikuriResearch Unit of Internal Medicine, University Hospital and University of Oulu, Kajaaninkatu 50, Oulu, Finland.
M Juhani JunttilaResearch Unit of Internal Medicine, University Hospital and University of Oulu, Kajaaninkatu 50, Oulu, Finland.
Philippe GoyetteMontreal Heart Institute, Université de Montréal, 5000 rue Bélanger, Montréal, Quebec, Canada.
Sara L PulitDepartment of Genetics, Center for Molecular Medicine, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Raha PazokiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, Praed St, Paddington, London, UK.
Michael W TanckDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Meibergdreef 9, AZ Amsterdam, The Netherlands.
Marieke T BlomDepartment of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, Meibergdreef 9, AZ Amsterdam, The Netherlands.
XiaoQing ZhaoCVPath Institute, 19 Firstfield Road, Gaithersburg, MD, USA.
Aki S HavulinnaNational Institute for Health and Welfare, Mannerheimintie 166, Helsinki, Finland.
Reza JabbariDepartment of Cardiology, Rigshospitalet, Inge Lehmanns Vej 7, Copenhagen, Denmark.
Charlotte GlingeDepartment of Cardiology, Rigshospitalet, Inge Lehmanns Vej 7, Copenhagen, Denmark.
Vinicius TraganteDepartment of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Stefan A EscherLund University Diabetes Centre, Department of Clinical Sciences, Lund University, Barngatan 4, Skånes universitetssjukhus, Malmo, Sweden.
Aravinda ChakravartiMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins, 733 N Broadway, Baltimore, MD, USA.
Georg EhretMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins, 733 N Broadway, Baltimore, MD, USA.
Josef CoreshDepartment of Epidemiology, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD, USA.
Man LiDepartment of Epidemiology, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD, USA.
Ronald J PrineasPublic Health Sciences, Wake Forest University, Medical Center Boulevard, Winston-Salem, NC, USA.
Oscar H FrancoInstitute of Social and Preventative Medicine, University of Bern, Mittelstrasse 43, Bern, Switzerland.
Pui-Yan KwokCardiovascular Research Institute and Institute for Human Genetics, University of California, San Francisco, 1550 4th Street, San Francisco, CA, USA.
Thomas LumleyDepartment of Statistics, University of Auckland, Private Bag 92014, Auckland, New Zealand.
Florence DumasParis Sudden Death Expertise Center, University Paris Descartes, Sorbonne Paris Cité, INSERM U970, 56 rue Leblanc, Paris, France.
Barbara McKnightCardiovascular Health Research Unit, Department of Medicine, University of Washington, 1730 Minor Ave, Seattle, WA, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA, USA.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, 1730 Minor Ave, Seattle, WA, USA.
Susan R HeckbertCardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1959 NE Pacific St, Seattle, WA, USA.
Christopher J O'DonnellNHLBI Framingham Heart Study, 73 Mount Wayte Avenue, Suite #2, Framingham, MA, USA.
Shih-Jen HwangCardiology Section, Department of Medicine, Boston VA Healthcare System, 1400 VFW Parkway, Boston, MA, USA.
Jean-Claude TardifMontreal Heart Institute, Université de Montréal, 5000 rue Bélanger, Montréal, Quebec, Canada.
Martin VanDenburghDivisions of Preventive Medicine and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave East, 3rd Floor, Boston, MA, USA.
André G UitterlindenErasmus MC University Medical Center, Department of Internal Medicine, Dr. Molewaterplein 40, CD Rotterdam, The Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus MC, Dr. Molewaterplein 50, GE Rotterdam, The Netherlands.
Bruno H C StrickerDepartment of Epidemiology, Erasmus MC, Dr. Molewaterplein 50, GE Rotterdam, The Netherlands.
Paul I W de BakkerDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Paul W FranksLund University Diabetes Centre, Department of Clinical Sciences, Lund University, Barngatan 4, Skånes universitetssjukhus, Malmo, Sweden.
Jan-Hakan JanssonDepartment of Public Health and Clinical Medicine, Research Unit Skelleftea, Umea University, University Hospital, Building 1A, 4st, Umea, Sweden.
Folkert W AsselbergsDepartment of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Marc K HalushkaDepartment of Pathology, Division of Cardiovascular Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Rm 632B, Baltimore, MD, USA.
Joseph J MaleszewskiDepartment of Laboratory Medicine & Pathology, Mayo Clinic, 3050 Superior Drive, Rochester, MN, USA.
Jacob Tfelt-HansenDepartment of Cardiology, Rigshospitalet, Inge Lehmanns Vej 7, Copenhagen, Denmark.
Thomas EngstrømDepartment of Cardiology, Rigshospitalet, Inge Lehmanns Vej 7, Copenhagen, Denmark.
Veikko SalomaaNational Institute for Health and Welfare, Mannerheimintie 166, Helsinki, Finland.
Renu VirmaniCVPath Institute, 19 Firstfield Road, Gaithersburg, MD, USA.
Frank KolodgieCVPath Institute, 19 Firstfield Road, Gaithersburg, MD, USA.
Arthur A M WildeAmsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ, Amsterdam, The Netherlands.
Hanno L TanAmsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ, Amsterdam, The Netherlands.
Connie R BezzinaAmsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ, Amsterdam, The Netherlands.
Mark EijgelsheimDepartment of Nephrology, University Medical Center Groningen, Hanzeplein 1, GZ, Groningen, The Netherlands.
John D RiouxMontreal Heart Institute, Université de Montréal, 5000 rue Bélanger, Montréal, Quebec, Canada.
Xavier JouvenParis Sudden Death Expertise Center, University Paris Descartes, Sorbonne Paris Cité, INSERM U970, 56 rue Leblanc, Paris, France.
Stefan KääbDepartment of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University, Marchioninistr. 15, Munich, Germany.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, 1730 Minor Ave, suite #1360, Seattle, WA, USA.
David S SiscovickThe New York Academy of Medicine, 1216 5th Ave, New York, New York, USA.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins, 733 N Broadway, Baltimore, MD, USA.
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, 1730 Minor Ave, Seattle, WA, USA.
Johns Hopkins University · USUniversity of Washington · USCVPath Institute · USErasmus MC · NLRigshospitalet · DKAmsterdam Neuroscience · NLAmsterdam UMC Location University of Amsterdam · NLBrigham and Women's Hospital · USFinnish Institute for Health and Welfare · FIHeidelberg University · DELudwig-Maximilians-Universität München · DEUniversité de Montréal · CAUniversity Medical Center Utrecht · NLUniversity of California, San Francisco · USVA Boston Healthcare System · USAmsterdam University Medical Centers · NLCenter for Human Genetics · USErasmus University Rotterdam · NLImperial College London · GBInserm · FR

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Physicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
PRE-DETERMINE: Biologic Markers and MRI SCD Cohort StudyR01HL091069 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALBERT, CHRISTINE M · 2008 to 2020
$12.9M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Predoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6M
NCATS NIH HHS UL1 TR001881NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA097193NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL034595NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL046959NHLBI NIH HHS R01 HL054776NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL068070NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL088456NHLBI NIH HHS R01 HL088576NHLBI NIH HHS R01 HL091069NHLBI NIH HHS R01 HL091244NHLBI NIH HHS R01 HL092111NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01 HL111267NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIA NIH HHS R56 AG023629NIDDK NIH HHS P30 DK063491NIGMS NIH HHS R01 GM104469NIGMS NIH HHS T32 GM007814
6 · The paper itself

Abstract

Aims: Sudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and to identify risk factors causally associated with SCA. Methods and results: We carried out a large genome-wide association study (GWAS) for SCA (n = 3939 cases, 25 989 non-cases) to examine common variation genome-wide and in candidate arrhythmia genes. We also exploited Mendelian randomization (MR) methods using cross-trait multi-variant genetic risk score associations (GRSA) to assess causal relationships of 18 risk factors with SCA. No variants were associated with SCA at genome-wide significance, nor were common variants in candidate arrhythmia genes associated with SCA at nominal significance. Using cross-trait GRSA, we established genetic correlation between SCA and (i) coronary artery disease (CAD) and traditional CAD risk factors (blood pressure, lipids, and diabetes), (ii) height and BMI, and (iii) electrical instability traits (QT and atrial fibrillation), suggesting aetiologic roles for these traits in SCA risk. Conclusions: Our findings show that a comprehensive approach to the genetic architecture of SCA can shed light on the determinants of a complex life-threatening condition with multiple influencing factors in the general population. The results of this genetic analysis, both positive and negative findings, have implications for evaluating the genetic architecture of patients with a family history of SCA, and for efforts to prevent SCA in high-risk populations and the general community.

Indexed as

Arrhythmias, CardiacBody Mass IndexCoronary Artery DiseaseDeath, Sudden, CardiacFemaleGenome-Wide Association StudyHeart Conduction SystemHumansMaleMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk AssessmentRisk FactorsSex Factors

Identifiers

PMID30169657
PMCPMC6247663
OpenAlexW2777050540

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.