ArticleJournal of animal science2018
Dietary sulfur amino acids affect jejunal cell proliferation and functions by affecting antioxidant capacity, Wnt/β-catenin, and the mechanistic target of rapamycin signaling pathways in weaning piglets.
Article in Journal of animal science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Oxidative stress affects intestinal health by inhibiting the differentiation of porcine intestinal epithelial cells through producing arachidonic acid.Science China. Life sciences · 2026Article
- Intestinal organoid screen reveals that Bacillus velezensis PGM541 promotes epithelial proliferation via its metabolite butyric acid.Microbiome · 2026Article
- Effects of dietary digestible energy levels on growth performance, intestinal function, carcass traits, meat quality and blood biochemical parameters of Ningxiang pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Methionine metabolism, functions, and application in swine.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Integrated Transcriptome and Metabolome Analysis of the Porcine Small Intestine During Weaning.Genes · 2025Article
- Baicalin-copper complex alleviates intestinal damage in avian pathogenicFrontiers in veterinary science · 2025Article
- Methionine ameliorates intestinal injury in senescence-accelerated mouse prone-8 mice by reducing sulfate-reducing bacteria and enhancing barrier function.Frontiers in nutrition · 2025Article
- Supplementing Monosodium Glutamate in Sow Diets Enhances Reproductive Performance in Lactating Sows and Improves the Growth of Suckling Piglets.Animals : an open access journal from MDPI · 2024Article
- Dietary cystine restriction increases the proliferative capacity of the small intestine of mice.PloS one · 2024Article
- Formulating Diets for Improved Health Status of Pigs: Current Knowledge and Perspectives.Animals : an open access journal from MDPI · 2022Review
- The developmental changes in intestinal epithelial cell proliferation, differentiation, and shedding in weaning piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Article
- Changes in progenitors and differentiated epithelial cells of neonatal piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Higher niacin intakes improve the lean meat rate of Ningxiang pigs by regulating lipid metabolism and gut microbiota.Frontiers in nutrition · 2022Article
- Weaning stress and intestinal health of piglets: A review.Frontiers in immunology · 2022Review
- Dietary high protein-induced diarrhea and intestinal inflammation by activation of NF-κB signaling in piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Use of low dosage amino acid blends to prevent stress-related piglet diarrhea.Translational animal science · 2021Article
- Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide-rich springs.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Functional amino acids, growth and immunity.Journal of animal science · 2021Article
- Imbalanced dietary methionine-to-sulfur amino acid ratio can affect amino acid profiles, antioxidant capacity, and intestinal morphology of piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal epithelial cells undergo rapid renewal along the crypt-villus axis (CVA), which ensures intestinal functions. Weaning stress differentially effects intestinal epithelial cell metabolism and physiological states along the CVA. Sulfur amino acids (SAA) play a key role in intestinal epithelial cell functioning. This study evaluated the effects of SAA dietary supplementation on weaning pig jejunal epithelial cells along the CVA. Sixteen Duroc × Landrace × Yorkshire piglets (6.16 ± 0.22 kg BW) were weaned at 21 d of age and were blocked by BW and gender and the randomly assigned to 1 of 2 groups fed diets consisting of low (0.53%) or high (0.85%) levels of SAA for a 7-d period. All piglets were euthanized for tissue sampling on day 7 postweaning. Jejunal epithelial cells were isolated along the CVA to yield 3 "cell fractions" (upper villus, middle villus, and crypt cells). The number of proliferating cells per crypt of piglets fed the high SAA diet was lower (P < 0.05) than that for low SAA diet. High SAA diet piglets tended to have decreased (P = 0.059) sucrase activities compared low SAA diet piglets. A high SAA diet increased (P < 0.05) total antioxidant capacity, catalase, and superoxide dismutase activities compared with a low SAA diet. mRNA expression levels of claudin-1, Slc5a1, and Slc7a9 in high SAA diet piglets were lower (P < 0.05) than for low SAA diet piglets. There were no interactions between dietary SAA and cell sections along the CVA for enzyme activities and mRNA expression in any of the weaned piglets. Protein amounts and phosphorylation levels related to Wnt/β-catenin and mechanistic targeting of rapamycin (mTOR) signaling pathways were affected by SAA in weaning piglets. These findings indicate that dietary SAA affects jejunal cell proliferation and functions in weaning piglets. There appears to be no interactions between dietary SAA and cell sections along the CVA. The effects of SAA may be partly through affecting antioxidant capacity, and Wnt/β-catenin and mTOR signaling pathway.
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