ArticleCerebral cortex (New York, N.Y. : 1991)2019
Domain-Specific Diaschisis: Lesions to Parietal Action Areas Modulate Neural Responses to Tools in the Ventral Stream.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Manipulable object processing reveals distinct neural and behavioral signatures for visual, functional, and manipulation properties.Communications psychology · 2026Article
- Visual processing of manipulable objects in the ventral stream is modulated by parietal action systems.Brain communications · 2026Article
- Object-directed action representations are componentially built in parietal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Causal Lesion Evidence for Two Motor Speech Coordination Networks in the Brain.bioRxiv : the preprint server for biology · 2025Article
- Left-hemisphere glioma drives systematic patterns of contralesional functional connectivity.Brain communications · 2025Article
- Lesion-network mapping in task-dependent frequencies uncovers remote consequences of focal damage.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Reciprocal interactions among parietal and occipito-temporal representations support everyday object-directed actions.Neuropsychologia · 2024Article
- Temporal differences and commonalities between hand and tool neural processing.Scientific reports · 2023Article
- Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy.Developmental cognitive neuroscience · 2023Article
- Neural and behavioral signatures of the multidimensionality of manipulable object processing.Communications biology · 2023Article
- Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy.bioRxiv : the preprint server for biology · 2023Article
- Pulvinar Response Profiles and Connectivity Patterns to Object Domains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Single-case disconnectome lesion-symptom mapping: Identifying two subtypes of limb apraxia.Neuropsychologia · 2022Article
- Domain-specific connectivity drives the organization of object knowledge in the brain.Handbook of clinical neurology · 2022Review
- Neural encoding and functional interactions underlying pantomimed movements.Brain structure & function · 2021Article
- Tool heads prime saccades.Scientific reports · 2021Article
- High-Level Representations in Human Occipito-Temporal Cortex Are Indexed by Distal Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Domain-specific functional coupling between dorsal and ventral systems during action perception.Scientific reports · 2020Article
- Altered large-scale organization of shape processing in visual agnosia.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Neural responses to small manipulable objects ("tools") in high-level visual areas in ventral temporal cortex (VTC) provide an opportunity to test how anatomically remote regions modulate ventral stream processing in a domain-specific manner. Prior patient studies indicate that grasp-relevant information can be computed about objects by dorsal stream structures independently of processing in VTC. Prior functional neuroimaging studies indicate privileged functional connectivity between regions of VTC exhibiting tool preferences and regions of parietal cortex supporting object-directed action. Here we test whether lesions to parietal cortex modulate tool preferences within ventral and lateral temporal cortex. We found that lesions to the left anterior intraparietal sulcus, a region that supports hand-shaping during object grasping and manipulation, modulate tool preferences in left VTC and in the left posterior middle temporal gyrus. Control analyses demonstrated that neural responses to "place" stimuli in left VTC were unaffected by lesions to parietal cortex, indicating domain-specific consequences for ventral stream neural responses in the setting of parietal lesions. These findings provide causal evidence that neural specificity for "tools" in ventral and lateral temporal lobe areas may arise, in part, from online inputs to VTC from parietal areas that receive inputs via the dorsal visual pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.