ArticleCerebral cortex (New York, N.Y. : 1991)2019
Maturation of the Human Cerebral Cortex During Adolescence: Myelin or Dendritic Arbor?
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Repurposing medications to prevent psychosis.Npj mental health research · 2025Review
- Decreased prefrontal glutamatergic function is associated with a reduced astrocyte-related gene expression in treatment-resistant depression.Translational psychiatry · 2024Article
- Regional patterns of human cortex development correlate with underlying neurobiology.Nature communications · 2024Article
- Regional patterns of human cortex development correlate with underlying neurobiology.bioRxiv : the preprint server for biology · 2024Article
- Unraveling the molecular relevance of brain phenotypes: A comparative analysis of null models and test statistics.NeuroImage · 2024Article
- How Physical Exercise Reduces Problematic Mobile Phone Use in Adolescents: The Roles of Expression Suppression, Depression, Anxiety, and Resilience.Psychology research and behavior management · 2024Article
- Population Neuroscience: Principles and Advances.Current topics in behavioral neurosciences · 2024Review
- Development and Maturation of the Human Brain, from Infancy to Adolescence.Current topics in behavioral neurosciences · 2024Review
- Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration.Brain : a journal of neurology · 2023Article
- Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysis.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure.Translational psychiatry · 2023Article
- Neurofilament light-associated connectivity in young-adult Huntington's disease is related to neuronal genes.Brain : a journal of neurology · 2022Article
- Imaging Transcriptomics of Brain Disorders.Biological psychiatry global open science · 2022Review
- Obesity-Related Neuroinflammation: Magnetic Resonance and Microscopy Imaging of the Brain.International journal of molecular sciences · 2022Review
- An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.Human brain mapping · 2022Review
- Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.Human brain mapping · 2022Review
- Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs.Human brain mapping · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Previous in vivo studies revealed robust age-related variations in structural properties of the human cerebral cortex during adolescence. Neurobiology underlying these maturational phenomena is largely unknown. Here we employ a virtual-histology approach to gain insights into processes associated with inter-regional variations in cortical microstructure and its maturation, as indexed by magnetization transfer ratio (MTR). Inter-regional variations in MTR correlate with inter-regional variations in expression of genes specific to pyramidal cells (CA1) and ependymal cells; enrichment analyses indicate involvement of these genes in dendritic growth. On the other hand, inter-regional variations in the change of MTR during adolescence correlate with inter-regional profiles of oligodendrocyte-specific gene expression. Complemented by a quantitative hypothetical model of the contribution of surfaces associated with dendritic arbor (1631 m2) and myelin (48 m2), these findings suggest that MTR signals are driven mainly by macromolecules associated with dendritic arbor while maturational changes in the MTR signal are associated with myelination.
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