ArticlePloS one2018
Genomics-guided discovery and structure identification of cyclic lipopeptides from the Bacillus siamensis JFL15.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 51 citations in OpenAlex.
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- Phenotypic, secondary metabolite, and genomic characterization of Bacillus siamensis B03 from brackish water with Anti‑Vibrio potential.Archives of microbiology · 2025Article
- Bacillibactin, a PotentialInternational journal of molecular sciences · 2025Article
- Antimicrobial Activity ofInternational journal of molecular sciences · 2025Review
- Antifungal potential of lipopeptides produced by theMicrobiology spectrum · 2024Article
- Targeted Isolation of Antibiofilm Compounds from Halophytic EndophyteMicroorganisms · 2024Article
- Detection of Antagonistic Compounds Synthesized byMicroorganisms · 2023Article
- Isolation and Genome-Based Characterization of Biocontrol Potential ofJournal of fungi (Basel, Switzerland) · 2023Article
- Bacterial hitchhikers derive benefits from fungal housing.Current biology : CB · 2022Article
- Identification, Characterization, and Efficacy Evaluation of Bacillus velezensis for Shot-Hole Disease Biocontrol in Flowering Cherry.The plant pathology journal · 2022Article
- Genomic and Experimental Analysis of the Biostimulant and Antagonistic Properties of Phytopathogens ofMicroorganisms · 2022Article
- A taxonomically representative strain collection to explore xenobiotic and secondary metabolism in bacteria.PloS one · 2022Article
- Comparative Study ofFrontiers in cellular and infection microbiology · 2022Article
- A Review on the Biotechnological Applications of the Operational GroupMicroorganisms · 2021Review
- Metagenomic analysis and antimicrobial activity of two fermented milk kefir samples.MicrobiologyOpen · 2021Article
- Antifungal Activity of Cyclic Tetrapeptide fromPathogens (Basel, Switzerland) · 2021Article
- Screening of Tomato Seed Bacterial Endophytes for Antifungal Activity Reveals Lipopeptide ProducingFrontiers in microbiology · 2021Article
- Antimicrobial Activities of Lipopeptides and Polyketides ofMolecules (Basel, Switzerland) · 2020Review
- Structural and Functional Insights into Iturin W, a Novel Lipopeptide Produced by the Deep-Sea BacteriumApplied and environmental microbiology · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this research, a strain with broad-spectrum antimicrobial activities was isolated from the gastrointestinal tract of hairtail (Trichiurus haumela) and identified as Bacillus siamensis JFL15 through morphological, 16S rRNA, and average nucleotide identity analyses. The genome of B. siamensis JFL15 was sequenced, and three gene clusters involved in the biosynthesis of surfactin (srf), bacillibactin (dhb), and fengycin (fen) were predicted through antiSMASH analysis. The combined genomics-metabolics profiling of the strain revealed 20 active compounds, which belong to four main types of cyclic lipopeptides produced by Bacillus species: bacillibactin, iturin, fengycin, and surfactin. Among these lipopeptides, two high-purity antifungal components, namely, components b and c, were successfully identified as iturin A and bacillomycin F. The minimum inhibitory concentrations (MICs) of iturin A for Magnapothe grisea, Rhizoctorzia solani, and Colletotrichum gloeosporioides were 125.00, 62.50, and 125.00 μg/ml, respectively, whereas the MICs of bacillomycin F for these three organisms were 62.50, 31.25, and 62.50 μg/ml, respectively. The mechanism of bacillomycin F and iturin A against M. grisea was also investigated. Scanning electron microscopy (SEM) indicated that the surface of the hypha treated with iturin A or bacillomycin F became sunk, lumpy, and wrinkled. The diversity of the identified and predicted compounds from B. siamensis JFL15 suggested that this strain might be a promising biocontrol agent for an effective and environmentally friendly control of pathogenic microorganisms. To the best of our knowledge, this study is the first to describe cyclic lipopeptides purified and identified from B. siamensis.
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