ArticlePLoS biology2018
Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model.Biological research · 2024Article
- Role and mechanism of PVN-sympathetic-adipose circuit in depression and insulin resistance induced by chronic stress.EMBO reports · 2023Article
- Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage.Life (Basel, Switzerland) · 2022Article
- Delayed body development with reduced triglycerides levels in leptin transgenic pigs.Transgenic research · 2022Article
- Phospho-SerCancers · 2021Article
- Metabolic determinants of lupus pathogenesis.Immunological reviews · 2020Review
- Leptin: an unappreciated key player in SLE.Clinical rheumatology · 2020Review
- Association ofBioMed research international · 2020Article
- Endogenous leptin promotes autophagy in EBSS-induced PFCs.Animal cells and systems · 2019Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
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Abstract
Leptin is a well-known adipokine that plays a critical role in immune responses. To further explore the immunological roles of leptin, we developed a transgenic leptin pig controlled by the pig leptin (pleptin) promoter to overexpress leptin. Symptoms typically associated with systemic lupus erythematosus (SLE) were evident in this transgenic pig strain, including anemia, leukopenia, and thrombocytopenia as well as kidney and liver impairment. Histologically, there were increased immunoglobulin G (IgG) levels, elevated antiplatelet antibody (APA) levels, and deposition of immune complexes in the kidney and liver. In addition, anti-double-stranded DNA antibodies (dsDNAs), antinuclear antibodies (ANAs), and antinucleosome antibodies (ANuAs) were all significantly increased in serum immunological examinations. These findings were also accompanied by repression of the regulatory T cell (Treg) ratio. Significantly, glucocorticoid experimental therapies partially relieved the autoimmune responses and bleeding symptoms observed in these transgenic leptin pigs. Together, these results indicate that leptin plays a critical role in the development of autoimmune disorders and demonstrate that our transgenic leptin pigs can act as a valuable model of SLE.
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