Evidence map›Paper›PMID 30169116›Full record

ReviewAnnals of medicine2018

Implications of low muscle mass across the continuum of care: a narrative review.

Carla M Prado, Sarah A Purcell, Carolyn Alish, Suzette L Pereira, Nicolaas E Deutz, Daren K Heyland, Bret H Goodpaster, Kelly A Tappenden, Steven B Heymsfield

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04791540 (Observational Pilot Study in Patients Who Underwent Tracheostomy), which is not on this map. Cited by 162 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 13 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04791540 recruitingnot on this mapstarted 2021, after this paper: background citation

Observational Pilot Study in Patients Who Underwent Tracheostomy: Sarcopenia Assessment by Handgrip Strenght and BIA. Association to Malnutrion Risk, Nutritional Status, Gut Microbioma and Decannulation Time.

TypeobservationalSponsorFondazione Don Carlo Gnocchi ETSRan2021 to 2025Enrolled30ConditionsSarcopeniaArmshandgrip strenght, Bioelectrical Impedance Analysis (BIA), MUST, GLIM, Gut microbiota
3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 13 syntheses or guidelines pooled it, 254 citations in OpenAlex.

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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Carla M Pradoa Department of Agricultural, Food and Nutritional Science, Division of Human Nutrition , University of Alberta , Edmonton , Alberta , Canada.
Sarah A Purcella Department of Agricultural, Food and Nutritional Science, Division of Human Nutrition , University of Alberta , Edmonton , Alberta , Canada.
Carolyn Alishb Abbott Nutrition, Abbott Laboratories , Columbus , OH , USA.
Suzette L Pereirab Abbott Nutrition, Abbott Laboratories , Columbus , OH , USA.
Nicolaas E Deutzc Center for Translational Research in Aging and Longevity, Department of Health and Kinesiology , Texas A and M University , TX , USA.
Daren K Heylandd Kingston General Hospital , Clinical Evaluation Research Unit , Kingston , Ontario , Canada.
Bret H Goodpastere Florida Hospital, Sanford Burnham Prebys Medical Discovery Institute , Translational Research Institute for Metabolism and Diabetes , Orlando , FL , USA.
Kelly A Tappendenf Department of Food Science and Human Nutrition , University of Illinois at Urbana-Champaign , Urbana , IL , USA.
Steven B Heymsfieldg Pennington Biomedical Research Center , Baton Rouge , LA , USA.
University of Alberta · CAAbbott (United States) · USClinical Evaluation Research Unit · CAPennington Biomedical Research Center · USRoss Laboratories (United States) · USSanford Burnham Prebys Medical Discovery Institute · USUniversity of Illinois Urbana-Champaign · US

Funding

Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trial of Combined Cycle Ergometry and Amino Acids in the ICUR01HL132887 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HEYLAND, DAREN KEITH, NEEDHAM, DALE MURRAY · 2017 to 2021
$3.5M
TARGETED GENOMICS FACILITY COREP30ES023512 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI THREADGILL, DAVID W. · 2014 to 2017
$3.3M
CIHRNHLBI NIH HHS R01 HL132887NIEHS NIH HHS P30 ES023512
6 · The paper itself

Abstract

Abnormalities in body composition can occur at any body weight. Low muscle mass is a predictor of poor morbidity and mortality and occurs in several populations. This narrative review provides an overview of the importance of low muscle mass on health outcomes for patients in inpatient, outpatient and long-term care clinical settings. A one-year glimpse at publications that showcases the rapidly growing research of body composition in clinical settings is included. Low muscle mass is associated with outcomes such as higher surgical and post-operative complications, longer length of hospital stay, lower physical function, poorer quality of life and shorter survival. As such, the potential clinical benefits of preventing and reversing this condition are likely to impact patient outcomes and resource utilization/health care costs. Clinically viable tools to measure body composition are needed for routine screening and intervention. Future research studies should elucidate the effectiveness of multimodal interventions to counteract low muscle mass for optimal patient outcomes across the healthcare continuum. Key messages Low muscle mass is associated with several negative outcomes across the healthcare continuum. Techniques to identify and counteract low muscle mass in clinical settings are needed.

Indexed as

Continuity of Patient CareBody CompositionBody WeightHumansLength of StayMuscle, SkeletalMuscular AtrophyQuality of LifeWasting SyndromeBody compositioncardiovascular diseasescritical illnessgeneral surgeryliver diseaseslong-term carelow muscle massneoplasmsprimary health carepulmonary diseasesarcopenia

Identifiers

PMID30169116
PMCPMC6370503
OpenAlexW2889388367

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.