Evidence map›Paper›PMID 30168090›Full record

ArticleInternational journal of clinical oncology2019

Long-term influence of adjuvant breast radiotherapy on cognitive function in breast cancer patients treated with conservation therapy.

Osamu Shibayama, Kazuhiro Yoshiuchi, Masatoshi Inagaki, Yutaka Matsuoka, Eisho Yoshikawa, Yuriko Sugawara, Tatsuo Akechi, Noriaki Wada, Shigeru Imoto, Koji Murakami and 2 more

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Article in International journal of clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Long-Term Cognitive Dysfunction in Cancer Survivors.Frontiers in molecular biosciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Osamu ShibayamaDepartment of Psychosomatic Internal Medicine, Yokohama-Rosai Hospital, 3211 Kozukue-cho, Kohoku-ku, Yokohama, Japan.
Kazuhiro YoshiuchiDepartment of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Masatoshi InagakiDepartment of Neuropsychiatry, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, Japan.
Yutaka MatsuokaDivision of Health Care Research, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.
Eisho YoshikawaDepartment of Neuropsychiatry, Nippon Medical School, 1-7-1 Nagayama, Tama city, Tokyo, Japan.
Yuriko SugawaraNISSAN Motor Health Insurance Society, 2-6-32-20 Takashima, Nishi-ku, Yokohama, Japan.
Tatsuo AkechiDepartment of Psychiatry and Cognitive-Behavior Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Japan.
Noriaki WadaDepartment of General Surgery, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa, Japan.
Shigeru ImotoDepartment of Breast Surgery, Kyorin University Hospital, 6-20-2 Shinkawa, Mitaka, Japan.
Koji MurakamiDepartment of Radiology, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, Japan.
Asao OgawaPsycho-Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kshiwa, Japan.
Yosuke UchitomiInnovation Center for Supportive, Palliative, and Psychosocial Care, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. yuchitom@ncc.go.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mechanisms underlying cognitive decline after radiotherapy not directed at brain areas remains unclear. We previously suggested that adjuvant breast radiotherapy in breast conservation therapy could lower memory function soon after therapy, and that the process might be partially mediated by plasma interleukin (IL)-6 levels. The present study investigated how that relationship changes longitudinally.

methodsWe performed the Wechsler Memory Scale-Revised (WMS-R) test and measured plasma IL-6 levels for 47 breast cancer surgical patients within 1 year after the initial therapy (study 1) and more than 2 years after study 1 (study 2). We also performed 2 × 2 mixed [the radiotherapy group (n = 25) or the no-radiotherapy group (n = 22) × study 1 or study 2] analysis of covariance on the WMS-R indices and plasma IL-6 levels. The association between changes in plasma IL-6 levels and changes in the WMS-R indices between the two studies was evaluated using Pearson's correlation coefficient.

resultsThe Immediate Verbal Memory Index was significantly higher in study 2. The Delayed Recall Index was significantly higher in study 2 and significantly lower in the radiotherapy group only in study 1. There was a significant correlation between changes in plasma IL-6 levels and changes only in the Delayed Recall Index of the WMS-R.

conclusionsMemory decline in breast cancer patients soon after adjuvant breast radiotherapy was restored approximately 3 years after treatment, and decreased plasma IL-6 levels might be involved in the recovery process.

Indexed as

Mastectomy, SegmentalAdolescentAdultBiomarkers, TumorBreast NeoplasmsCognitionFemaleHumansInterleukin-6Longitudinal StudiesMemoryMiddle AgedRadiotherapy, AdjuvantTime FactorsYoung AdultBiomarkers, TumorInterleukin-6Breast cancerCognitive declineInterleukin-6Longitudinal studyRadiotherapy

Identifiers

PMID30168090

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.