Evidence map›Paper›PMID 30168083›Full record

Observational studyJournal of nephrology2019

Left Atrial Remodeling Assessed by Cardiac MRI after Conversion from Conventional Hemodialysis to In-Centre Nocturnal Hemodialysis.

Tamryn K Law, Ron Wald, Marc Goldstein, Gauri R Karur, Ming-Yen Ng, Angela Y M Wang, Djeven P Deva, Anish Kirpalani, Rachel M Wald, Mercedeh Kiaii and 3 more

Registry-linked trialAbstract readComparative StudyMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00718848 (Impact of In-centre Nocturnal Hemodialysis on Ventricular Remodeling and Function in End-stage Renal Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00718848 completednot on this map

Impact of In-centre Nocturnal Hemodialysis on Ventricular Remodeling and Function in End-stage Renal Disease

TypeobservationalSponsorUnity Health TorontoRan2008 to 2012Enrolled67ConditionsEnd-stage Renal Disease, Left Ventricular HypertrophyArmsIncentre nocturnal hemodialysis, Remaining on conventional hemodialysis
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Cardiovascular Biomarkers in Nocturnal Hemodialysis and Their Association With Physical Performance.Hemodialysis international. International Symposium on Home Hemodialysis · 2025
    Article
  2. P Wave Peak Time for Predicting an Increased Left Atrial Volume Index in Hemodialysis Patients.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020
    Article
  3. Review
  4. Article
  5. Nocturnal hemodialysis: improved quality of life and patient outcomes.International journal of nephrology and renovascular disease · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tamryn K LawDivision of Cardiology, Terrence Donnelly Heart Centre, St. Michael's Hospital, Toronto, ON, Canada.
Ron WaldUniversity of Toronto, Toronto, ON, Canada.
Marc GoldsteinUniversity of Toronto, Toronto, ON, Canada.
Gauri R KarurDepartment of Medical Imaging, Li Ka Shing Knowledge Institute, Keenan Research Centre, St. Michael's Hospital, Toronto, ON, Canada.
Ming-Yen NgDepartment of Diagnostic Radiology, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Angela Y M WangDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong.
Djeven P DevaUniversity of Toronto, Toronto, ON, Canada.
Anish KirpalaniUniversity of Toronto, Toronto, ON, Canada.
Rachel M WaldUniversity of Toronto, Toronto, ON, Canada.
Mercedeh KiaiiDivision of Nephrology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
Jonathon LeipsicDivision of Radiology and Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
Kim A ConnellyDivision of Cardiology, Terrence Donnelly Heart Centre, St. Michael's Hospital, Toronto, ON, Canada.
Andrew T YanDivision of Cardiology, Terrence Donnelly Heart Centre, St. Michael's Hospital, Toronto, ON, Canada. yana@smh.ca.

Funding

Canadian Institutes of Health Research MOP-89982Heart and Stroke Foundation of Canada Project Number G-14-0005856
6 · The paper itself

Abstract

backgroundLeft atrial (LA) volume is a well-established cardiovascular prognosticator in patients with end-stage renal disease. Although dialysis intensification is associated with left ventricular mass regression, there are limited data regarding LA remodeling. Using cardiac magnetic resonance imaging (CMR), we examined changes in LA size and function relative to ventricular remodeling and cardiac biomarkers after dialysis intensification.

methodsIn this prospective 2-centre cohort study, 37 patients receiving conventional hemodialysis (CHD, 4 h/session, 3×/week) were converted to in-centre nocturnal hemodialysis (INHD 7-8 h/session, 3×/week); 30 patients remained on CHD. CMR and biomarkers were performed at baseline and repeated at 52 weeks.

resultsAfter 52 weeks, there were no significant changes in the LA volumes or LA ejection fraction (EF) within either the CHD or INHD group, and no significant differences between the two groups. Correlations existed between changes in LA and LV end-diastolic volume index (EDVi, Spearman's r = 0.69, p < 0.001), LA and LV end-systolic volume index (ESVi, r = 0.44, p = 0.001), LAEF and LVEF (r = 0.28, p = 0.04), LA and RV EDVi (r = 0.51, p < 0.001), LA and RV ESVi (r = 0.29, p = 0.039), and LA ESVi and LV mass index (r = 0.31, p = 0.02). At baseline, indexed LA volumes positively correlated with NT-proBNP, whereas LAEF negatively correlated with NT-proBNP and Troponin I. After 52 weeks, changes in biomarker levels did not correlate with changes in LA volume or EF.

conclusionThere was no significant change in LA size or systolic function after conversion to INHD. The significant correlations between LA and ventricular remodeling and cardiac biomarkers suggest common underlying pathophysiologic mechanisms.

trial registrationClinicalTrials.gov Identifier: NCT00718848.

Indexed as

Atrial Function, LeftAtrial RemodelingMagnetic Resonance ImagingAdultAgedCanadaFemaleHeart AtriaHeart DiseasesHumansKidney Failure, ChronicMaleMiddle AgedPredictive Value of TestsProspective StudiesRenal DialysisCardiac MRIEnd-stage renal diseaseHemodialysisLeft atrium

Identifiers

PMID30168083

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.