ArticleSurgical endoscopy2019
Endoscopic resection of advanced ampullary adenomas: a single-center 14-year retrospective cohort study.
Article in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Therapeutic strategies and outcomes in the management of ampullary tumours: meta-analysis.BJS open · 2026Pooled it
- Prophylactic pancreatic duct stenting to reduce the risk of post-ampullectomy pancreatitis: a comprehensive review and meta-analysis of 1858 patients.Surgical endoscopy · 2024Pooled it
- A Comparison of Clinical Outcomes between Endoscopic Resection and Surgical Resection in Ampullary Tumors.Medicina (Kaunas, Lithuania) · 2020Pooled it
- Forward- vs. Oblique-Viewing Endoscope for Duodenal Papillectomy: A Comparative Study on Efficacy and Safety.Digestive diseases and sciences · 2026Article
- Clinical Validation of a Generative AI System for Diagnosing Ampullary Lesions: A Multicenter Study.United European gastroenterology journal · 2026Article
- Nationwide Survey on Endoscopic Papillectomy for Ampullary Adenoma: Current Practices and Variability.Gut and liver · 2026Article
- Endoscopic Management of Ampullary Adenomas: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Factors associated with delayed bleeding following ampullectomy: A retrospective cohort study.DEN open · 2025Article
- Article
- Endoscopic papillectomy of major papilla lesions: Single tertiary care center experience.Endoscopy international open · 2025Article
- Safety of intrabiliary radiofrequency ablation in cases of residual and recurrent neoplasia after endoscopic papillectomy.Endoscopy international open · 2025Review
- Effectiveness of endoscopic papillectomy with stent placement in pancreatic and bile ducts for treating duodenal papillary adenoma: a retrospective study.BMC gastroenterology · 2024Observational
- New Method of Papillectomy May Decrease Recurrence: Anchoring Method versus Conventional Method.Journal of clinical medicine · 2024Article
- Modified Endoscopic Submucosal Dissection-An Alternative Modality for the Treatment of Sporadic Duodenal Papillary Adenomas.Gastroenterology research and practice · 2024Article
- Updates on the Management of Ampullary Neoplastic Lesions.Diagnostics (Basel, Switzerland) · 2023Review
- Clinical outcomes: endoscopic resection of duodenal ampullary lesions.Translational gastroenterology and hepatology · 2023Article
- Long-term follow-up of endoscopic papillectomy and the value of preventive pancreatic stent placement (with videos).Gastroenterology report · 2023Article
- Screening for hilar biliary invasion in ampullary cancer patients.World journal of gastrointestinal endoscopy · 2022Article
- Impact of 5-Year Endoscopic Surveillance Intervals with Biopsy following Endoscopic Papillectomy for Ampullary Adenoma.Journal of personalized medicine · 2022Article
- Endoscopic papillectomy; a retrospective international multicenter cohort study with long-term follow-up.Surgical endoscopy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic ampullectomy has been recognized as a safe and reliable means to resect selective tumors of the ampulla of Vater and is associated with lower morbidity and mortality rates compared to surgical resection. Success rates range from 42 to 92%, with recurrences reported in up to 33%. Studies on endoscopic resection of advanced lesions such as those with intraductal extension of adenoma (IEA) and lateral spreading adenomas (LSA) are limited. We aimed to evaluate the technical success, complications, and recurrence of endoscopic resection of ampullary adenomas, including advanced lesions.
methodsAll patients referred to the Erasmus Medical Center for endoscopic resection of an ampullary lesion were retrospectively identified between 2002 and 2016. Endoscopic success was defined as complete excision of the adenoma, irrespective of the number of attempts, in the absence of recurrence.
resultsWe included 87 patients with a median age of 65 years. Of these, 56 patients (64%) had an adenoma confined to the ampulla (ACA), 20 patients (23%) had an LSA, and 11 patients (13%) were treated for an IEA. The median lesion sizes were 24.6 mm, 41.4 mm, and 16.3 mm, respectively (P < 0.001). Complications occurred in 22 patients (25.3%), of which hemorrhage was most prevalent (12.6%), followed by perforation (8.1%). Complications were equally divided (P = 0.874). The median follow-up duration was 21.1 months (12-45.9) for ACA, 14.7 months (4.2-34.5) for LSA, and 5.8 months (3.7-22.0) for IEA (P = 0.051). Endoscopic resection was curative in 87.5% of patients with an ACA, 85% in patients with an LSA, and in only one patient with an IEA (P < 0.001). Recurrence occurred in 10 patients (11.5%) (P = 0.733).
conclusionEndoscopic ampullectomy is safe and highly successful in selected patients with an adenoma with or without lateral spreading. Outcomes of endoscopic treatment adenomas with an intraductal extension are less favorable and in these cases surgery should be considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.