Evidence map›Paper›PMID 30167904›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2019

Nature versus nurture: the impact of nativity and site of treatment on survival for gastric cancer.

Jessica L Mueller, Danbee H Kim, Sahael Stapleton, Christy E Cauley, David C Chang, Cho Hyun Park, Kyo Young Song, John T Mullen

Open access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jessica L MuellerDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Danbee H KimCodman Institute for Clinical Effectiveness in Surgery, Massachusetts General Hospital, Boston, MA, USA.
Sahael StapletonCodman Institute for Clinical Effectiveness in Surgery, Massachusetts General Hospital, Boston, MA, USA.
Christy E CauleyCodman Institute for Clinical Effectiveness in Surgery, Massachusetts General Hospital, Boston, MA, USA.
David C ChangCodman Institute for Clinical Effectiveness in Surgery, Massachusetts General Hospital, Boston, MA, USA.
Cho Hyun ParkDepartment of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea.
Kyo Young SongDepartment of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea. skygs@catholic.ac.kr.
John T MullenDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Massachusetts General Hospital · USSeoul St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognosis of gastric cancer patients is better in Asia than in the West. Genetic, environmental, and treatment factors have all been implicated. We sought to explore the extent to which the place of birth and the place of treatment influences survival outcomes in Korean and US patients with localized gastric cancer.

methodsPatients with localized gastric adenocarcinoma undergoing potentially curative gastrectomy from 1989 to 2010 were identified from the SEER registry and two single institution databases from the US and Korea. Patients were categorized into three groups: Koreans born/treated in Korea (KK), Koreans born in Korea/treated in the US (KUS), and White Americans born/treated in the US (W), and disease-specific survival rates compared.

resultsWe identified 16,622 patients: 3,984 (24.0%) KK, 1,046 (6.3%) KUS, and 11,592 (69.7%) W patients. KK patients had longer unadjusted median (not reached) and 5-year disease-specific survival (81.6%) rates than KUS (87 months, 55.9%) and W (35 months, 39.2%; p < 0.001 for all comparisons) patients. This finding persisted on subset analyses of patients with stage IA tumors, without cardia/GEJ tumors, with > 15 examined lymph nodes, and treated at a US center of excellence. On multivariable analysis, KUS (HR 2.80, p < 0.001) and W (HR 5.79, p < 0.001) patients had an increased risk of mortality compared to KK patients.

conclusionsBoth the place of birth and the place of treatment significantly contribute to the improved prognosis of patients with gastric cancer in Korea relative to those in the US, implicating both nature and nurture in this phenomenon.

Indexed as

AdenocarcinomaAgedEmigrants and ImmigrantsFemaleGastrectomyHumansLymph Node ExcisionMaleMiddle AgedPrognosisRepublic of KoreaSEER ProgramStomach NeoplasmsSurvival RateUnited StatesEthnicityGastric cancerNativityOutcomesSurvivalTreatment

Identifiers

PMID30167904
OpenAlexW2883705796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.