Evidence map›Paper›PMID 30167890›Full record

ArticlePharmaceutical research2018

Fabrication of TPGS-Stabilized Liposome-PLGA Hybrid Nanoparticle Via a New Modified Nanoprecipitation Approach: In Vitro and In Vivo Evaluation.

Mengyuan Zhang, Jianhua He, Wenli Zhang, Jianping Liu

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Pharmaceutical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications.Frontiers in bioengineering and biotechnology · 2020
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mengyuan ZhangDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Jianhua HeDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Wenli ZhangDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Jianping LiuDepartment of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China. jianpingliu1293@163.com.

Funding

Jiangsu Province Ordinary College and University Innovative Research Programs KYLX_0614National Natural Science Foundation of China 81273466
6 · The paper itself

Abstract

purposeIn this study, a new modified nanoprecipitation approach that more efficient and simpler than conventional approach was developed to synthesize D-alpha-Tocopheryl polyethylene glycol 1000 succinate stabilized liposome-PLGA hybrid nanoparticle, loaded with simvastatin (ST-TLPN).

methodsThe optimum formulation was screened via investigation of the impact of TPGS mass within polymeric core and lipid shell on the physicochemical properties of nanoparticles respectively. FTIR, and drug release of ST-TLPN were also systematically determined. Finally, the cellular internalization was evaluated using the murine macrophage cell line, in vivo pharmacokinetic behavior and antiatherogenic efficacies were elaborately examined in atherosclerotic rabbit models.

resultsWith the weight ratio of TPGS-to-PLGA in organic phase of 30% and TPGS-to-lipid in aqueous phase of 35%, ST-TLPN exhibited core-shell structure, sub-100 nm size, EE% of over 90% and a slow release profile. The excellent cellular uptake was displayed in RAW264.7 cell line. Improved pharmacokinetic behavior, and enhanced antiatherogenic efficacy of ST-TLPN in the model animals were also revealed compared with ST-loaded PLGA nanoparticles.

conclusionThese findings suggest the modified nanoprecipitation method holds great potential for fabricating LPN, aided by the multiple functions of TPGS. And the prepared TLPN is a promising delivery system for use in the pharmaceutical field.

Indexed as

AnimalsAtherosclerosisDrug CarriersDrug LiberationHydroxymethylglutaryl-CoA Reductase InhibitorsLiposomesMiceNanoparticlesOxidative StressParticle SizePolylactic Acid-Polyglycolic Acid CopolymerRabbitsRAW 264.7 CellsSimvastatinSurface PropertiesVitamin EDrug CarriersHydroxymethylglutaryl-CoA Reductase InhibitorsLiposomesPolylactic Acid-Polyglycolic Acid CopolymerSimvastatintocophersolanVitamin Eantiatherogenic efficaciesD-alpha-Tocopheryl polyethylene glycol 1000 succinateliposome-PLGA hybrid nanoparticlemodified nanoprecipitation approach

Identifiers

PMID30167890

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.