ReviewJournal of neurology2018
Risk factors of suicidal ideation in Huntington's disease: literature review and data from Enroll-HD.
Review in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Diagnostic value of genetic testing in chorea: a retrospective monocentric study.Journal of neurology · 2026Article
- Suicidal Ideation and Sleep Disturbances Among People With Huntington Disease: Evidence From the HDBOI Study.Neurology. Clinical practice · 2025Article
- Separate and cumulative effect of risk and protective factors associated with suicidal ideation among Chinese infertile couples: a cross-sectional study.Frontiers in psychology · 2025Article
- The pathobiology of depression in Huntington's disease: an unresolved puzzle.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Perceived Chronic Traumatic Encephalopathy and Suicidality in Former Professional Football Players.JAMA neurology · 2024Article
- A pilot evaluation of an 8-week mindfulness-based stress reduction program for people with pre-symptomatic Huntington's disease.Journal of community genetics · 2023Article
- Palliative care in advanced Huntington's disease: a scoping review.BMC palliative care · 2023Article
- Identification of psychoeducation needs and an intervention response for pre-symptomatic Huntington's disease.Journal of community genetics · 2023Article
- Incidence of completed suicide and suicide attempts in a global prospective study of Huntington's disease.BJPsych open · 2021Article
- Psychiatric morbidity and poor follow-up underlie suboptimal functional and survival outcomes in Huntington's disease.BMC neurology · 2020Article
- Risk factors for suicidality in Huntington disease: An analysis of the 2CARE clinical trial.Neurology · 2019Article
- Loss-of-Huntingtin in Medial and Lateral Ganglionic Lineages Differentially Disrupts Regional Interneuron and Projection Neuron Subtypes and Promotes Huntington's Disease-Associated Behavioral, Cellular, and Pathological Hallmarks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Validation of Neuro-QoL and PROMIS Mental Health Patient Reported Outcome Measures in Persons with Huntington Disease.Journal of Huntington's disease · 2019Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Suicide is a leading cause of death in Huntington's disease (HD), following pneumonia. Up to one-fifth of individuals with HD report suicidal ideation. Identifying the risk factors of suicidal ideation in this clinical population is thus pivotal. Here, we review the literature on prevalence rates and risk factors of suicidal ideation in premanifest and manifest patients and re-evaluate them using the largest currently existing clinical dataset from the ongoing observational study "Enroll-HD" (N = 5709). Large scale studies yielded important insights regarding suicidal ideation in HD. However, estimated prevalence rates vary among studies and risk factors are still poorly understood. According to the Enroll-HD data, pre- and manifest disease stages are associated with current (5.8-10%) and a history of suicidal ideation (18.6-30.9%). Throughout the course of HD, a history of suicidal ideation and the presence of depressive symptoms were strongly associated with current suicidal ideation. However, while for premanifest individuals, socio-demographics and activities of daily living appear to be important, in manifest patients, suicidal ideation is more closely linked to anxiety, irritability, psychosis, and apathy. These results highlight the importance of treating depressive symptoms in patients with HD and addressing potential suicidal ideation during clinical monitoring. The relevance of risk factors may differ among premanifest and manifest patients.
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