ArticlePediatric radiology2019
Ultrasound-guided cervical puncture for nusinersen administration in adolescents.
Article in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- A Systematic Review of Procedural Complications from Transforaminal Lumbar Puncture for Intrathecal Nusinersen Administration in Patients with Spinal Muscular Atrophy.AJNR. American journal of neuroradiology · 2021Pooled it
- CT-guided Lumbar Puncture for Intrathecal Nusinersen Injection in Patients with Spinal Muscular Atrophy: Technical Effectiveness, Safety, and Radiation Dose.Clinical neuroradiology · 2026Article
- Surgical Access for Intrathecal Therapy in Spinal Muscular Atrophy with Spinal Fusion: Long-Term Outcomes of Lumbar Laminectomy.Journal of clinical medicine · 2025Article
- Unilateral interlaminar fenestration on the convex side provides a reliable access for intrathecal administration of nusinersen in spinal muscular atrophy: a retrospective study.Orphanet journal of rare diseases · 2023Article
- Population-based assessment of nusinersen efficacy in children with spinal muscular atrophy: a 3-year follow-up study.Brain communications · 2022Article
- Intrathecal catheter and port placement for nusinersen infusion in children with spinal muscular atrophy and spinal fusion.Pediatric radiology · 2021Article
- Nusinersen injections in adults and children with spinal muscular atrophy: a single-center experience.Diagnostic and interventional radiology (Ankara, Turkey) · 2020Article
- Ultrasound-assisted intrathecal injection of nusinersen in a patient with severe vertebral deformity: a case report.JA clinical reports · 2020Article
- Intrathecal administration of nusinersen for spinal muscular atrophy: report of three cases with severe spinal deformity.JA clinical reports · 2020Article
- Intrathecal nusinersen administration in adult spinal muscular atrophy patients with complex spinal anatomy.Therapeutic advances in neurological disorders · 2020Article
- Clinical Implication of Dosimetry of Computed Tomography- and Fluoroscopy-Guided Intrathecal Therapy With Nusinersen in Adult Patients With Spinal Muscular Atrophy.Frontiers in neurology · 2019Article
- Intrathecal Administration of Nusinersen Using the Ommaya Reservoir in an Adult with 5q-Related Spinal Muscular Atrophy Type 1 and Severe Spinal Deformity.Case reports in neurologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpinal muscular atrophy (SMA) is an autosomal-recessive disease affecting motor neurons and is the most common genetic cause of death in infants. Intrathecal nusinersen is the only therapy approved by the U.S. Food and Drug Administration for SMA. Deformities and spinal instrumentation from orthopedic surgeries are common in children with SMA, complicating traditional intrathecal access for nusinersen delivery. Cervical punctures are routinely performed in adults for cervical myelograms and should be considered for children with SMA as a viable form of intrathecal access.
objectiveThis retrospective study assessed technical feasibility and complications of ultrasound-guided cervical puncture for nusinersen administration. MATERIALS AND
methodsWe reviewed 14 consecutive ultrasound-guided cervical punctures for nusinersen administration with local anesthesia. We reviewed technical success and complications.
resultsAll procedures were technically successful. There were no major complications. Two minor complications included headaches that resolved by observation within 24 h after the procedure.
conclusionOur series describes a successful novel method of ultrasound-guided cervical spine access for intrathecal administration of nusinersen, adding to the armamentarium of procedures for delivering nusinersen to adolescents with challenging lumbar spine access caused by scoliosis and spinal instrumentation. This technique has the advantages of real-time ultrasound guidance and potential avoidance of general anesthesia in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.