ArticleJACC. Basic to translational science2017
Ticagrelor Removal From Human Blood.
Article in JACC. Basic to translational science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Drug Clearance and Dosing During CytoSorb Hemoadsorption: A Systematic Review.Critical care explorations · 2026Pooled it
- Clinical and Pre-Clinical Pharmacokinetics and Pharmacodynamics of Bentracimab.Clinical pharmacokinetics · 2023Pooled it
- Randomized pilot trial of intraoperative hemoadsorption in clopidogrel treated patients undergoing urgent coronary artery bypass grafting.Journal of cardiothoracic surgery · 2026Trial
- Antibiotics and Other Drugs Removal by the CytoSorbAntibiotics (Basel, Switzerland) · 2026Review
- Pharmacological Management of Thrombosis: Current State and Future Strategies.International journal of molecular sciences · 2026Review
- Antithrombotic drug removal with hemoadsorption during off-pump coronary artery bypass grafting.Journal of cardiothoracic surgery · 2024Article
- Hemoadsorption and Coagulation Systemic Rebalance in Patients Undergoing Nonelective Cardiac Surgery and Treated with Antithrombotics.Blood purification · 2024Article
- Intraoperative ticagrelor removal via hemoadsorption during on-pump coronary artery bypass grafting.JTCVS open · 2023Article
- Cost-Effectiveness and Budget Impact of a Novel Antithrombotic Drug Removal System to Reduce Bleeding Risk in Patients on Preoperative Ticagrelor Undergoing Cardiac Surgery.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023Article
- Fluorescence quenching-based immunological probe for ticagrelor monitoring.Frontiers in bioengineering and biotechnology · 2023Article
- Antithrombotic drug removal from whole blood using Haemoadsorption with a porous polymer bead sorbent.European heart journal. Cardiovascular pharmacotherapy · 2022Article
- A New Apheresis Device for Antithrombotic Drug Removal during Off-Pump Coronary Artery Bypass Surgery.Medicina (Kaunas, Lithuania) · 2022Article
- Reversal of Platelet Inhibition in Patients Receiving Ticagrelor.Reviews in cardiovascular medicine · 2022Review
- Management of perioperative bleeding risk in patients on antithrombotic medications undergoing cardiac surgery-a systematic review.Journal of thoracic disease · 2022Review
- Hemoadsorption of Rivaroxaban and Ticagrelor during Acute Type A Aortic Dissection Operations.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2022Article
- Mechanistic Considerations and Pharmacokinetic Implications on Concomitant Drug Administration During CytoSorb Therapy.Critical care explorations · 2022Review
- Perioperative risk and antiplatelet management in patients undergoing non-cardiac surgery within 1 year of PCI.Journal of thrombosis and thrombolysis · 2022Article
- Therapeutic Modulation of the Host Defense by Hemoadsorption with CytoSorbInternational journal of molecular sciences · 2021Article
- Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID-19.Pharmacology research & perspectives · 2021Article
- Uremic Toxins and Blood Purification: A Review of Current Evidence and Future Perspectives.Toxins · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the second set, performed in a recirculating manner, used human blood mixed with ticagrelor. Removal of ticagrelor from BSA solution reached values >99%. The peak removal rate was 99% and 94% from whole blood and 99.99% and 90% from plasma during 10 h and 3 to 4 h of recirculating experiments, respectively. In conclusion, hemadsorption robustly removes ticagrelor from BSA solution and human blood samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.