ArticleEmerging topics in life sciences2018
MicroED: a versatile cryoEM method for structure determination.
Article in Emerging topics in life sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Membrane protein structure and dynamics probed by MicroED.Biochemical Society transactions · 2026Review
- An integrated workflow for the structure elucidation of nanocrystalline powders.Communications chemistry · 2026Article
- Unraveling atomic complexity from frozen samples.Structural dynamics (Melville, N.Y.) · 2025Article
- Navigating the challenges of engineering composite specialized metabolite pathways in plants.The Plant journal : for cell and molecular biology · 2025Review
- AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography.Acta crystallographica. Section D, Structural biology · 2024Article
- Theoretical 3D electron diffraction electrostatic potential maps of proteins modeled with a multipolar pseudoatom data bank.Acta crystallographica. Section D, Structural biology · 2022Article
- The Peel-Blot Technique: A Cryo-EM Sample Preparation Method to Separate Single Layers from Multi-Layered or Concentrated Biological Samples.Journal of visualized experiments : JoVE · 2022Article
- MicroED for the study of protein-ligand interactions and the potential for drug discovery.Nature reviews. Chemistry · 2021Review
- Selecting a stable solid form of remdesivir using microcrystal electron diffraction and crystal structure prediction.RSC advances · 2021Article
- Review
- 2D Electron Crystallography of Membrane Protein Single-, Double-, and Multi-Layered Ordered Arrays.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED.Structure (London, England : 1993) · 2020Article
- Preparing samples from whole cells using focused-ion-beam milling for cryo-electron tomography.Nature protocols · 2020Article
- Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix.Acta crystallographica. Section D, Structural biology · 2019Article
- Macromolecular Nanocrystal Structural Analysis with Electron and X-Rays: A Comparative Review.Molecules (Basel, Switzerland) · 2019Review
- Next Generation Techniques for Determination of Protein-Protein Interactions: Beyond the Crystal Structure.Current pathobiology reports · 2019Article
- Editorial: Technical Advances in Cryo-Electron Microscopy.Frontiers in molecular biosciences · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
Micro-electron diffraction, or MicroED, is a structure determination method that uses a cryo-transmission electron microscope to collect electron diffraction data from nanocrystals. This technique has been successfully used to determine the high-resolution structures of many targets from crystals orders of magnitude smaller than what is needed for X-ray diffraction experiments. In this review, we will describe the MicroED method and recent structures that have been determined. Additionally, applications of electron diffraction to the fields of small molecule crystallography and materials science will be discussed.
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