Evidence map›Paper›PMID 30167375›Full record

ArticleIDCases2018

Varicella Zoster aseptic meningitis: Report of an atypical case in an immunocompetent patient treated with oral valacyclovir.

Martin Gnoni, Kamran Zaheer, Melinda M Vasser, Monider Singh, Aman Ajmeri, Stephanie R Harter, Abdul Mughees Rana, Rodrigo Aguilar

Open access · goldAbstract readCase Reports
In one paragraph

Article in IDCases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Atypical Presentation of Aseptic Meningitis Due to Varicella Zoster: A Case Report.Clinical practice and cases in emergency medicine · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A Rare Case of an Immunocompetent Male With Zoster Meningitis.Journal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Martin GnoniOur Lady of Bellefonte Hospital, 1000 St Christopher Dr, Ashland, KY 41101, United States.
Kamran ZaheerOur Lady of Bellefonte Hospital, 1000 St Christopher Dr, Ashland, KY 41101, United States.
Melinda M VasserOur Lady of Bellefonte Hospital, 1000 St Christopher Dr, Ashland, KY 41101, United States.
Monider SinghMarshall University, MU Internal Medicine Residency Program, 1249 15th Street, Huntington, WV 25701, United States.
Aman AjmeriMarshall University, MU Internal Medicine Residency Program, 1249 15th Street, Huntington, WV 25701, United States.
Stephanie R HarterMarshall University, MU Internal Medicine Residency Program, 1249 15th Street, Huntington, WV 25701, United States.
Abdul Mughees RanaMarshall University, MU Internal Medicine Residency Program, 1249 15th Street, Huntington, WV 25701, United States.
Rodrigo AguilarMarshall University, MU Internal Medicine Residency Program, 1249 15th Street, Huntington, WV 25701, United States.
Marshall University · USOur Lady of Bellefonte Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicella Zoster when described has the typical presentation of a dermatomal distribution of a rash and can further lead to CNS complications. This can be treated accordingly with the proper protocol, but if the presentation is atypical and the protocol is challenged or changed per specific patient outcomes, new developments can occur. Here we present a case of a 29-year-old Caucasian female that presented to the emergency department with headache, photophobia, and chills for 5 days. She was previously healthy and immunocompetent; CSF PCR analysis revealed a VZV infection causing acute aseptic meningitis with no shingles rash eruption on physical examination. The patient was not willing to stay hospitalized for the duration of the treatment. This gave us an opportunity to treat her with an oral, rather than IV, antiviral. The patient was successfully treated with oral valacyclovir 2 g Q6H after only receiving two days of IV acyclovir. To the best of our knowledge, this is the first reported case of a patient with VZV-associated meningitis successfully treated with oral valacyclovir.

Indexed as

Aseptic meningitisAtypical meningitisCranial nerve deficitsImmunocompetentOral valacyclovirVaricella Zoster virus

Identifiers

PMID30167375
PMCPMC6115539
OpenAlexW2888241654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.