Evidence map›Paper›PMID 30167297›Full record

ArticleLight, science & applications2017

Endowing a plain fluidic chip with micro-optics: a holographic microscope slide.

Vittorio Bianco, Biagio Mandracchia, Valentina Marchesano, Vito Pagliarulo, Federico Olivieri, Sara Coppola, Melania Paturzo, Pietro Ferraro

Abstract read
In one paragraph

Article in Light, science & applications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
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  4. Artificial intelligence in imaging flow cytometry.Frontiers in bioinformatics · 2023
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  7. Review
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  15. Article
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  18. Deep learning in holography and coherent imaging.Light, science & applications · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vittorio BiancoInstitute of Applied Sciences and Intelligent Systems-Italian National Research Council (ISASI-CNR), Via Campi Flegrei 34, Pozzuoli, Napoli 80078, Italy.
Biagio MandracchiaInstitute of Applied Sciences and Intelligent Systems-Italian National Research Council (ISASI-CNR), Via Campi Flegrei 34, Pozzuoli, Napoli 80078, Italy.
Valentina MarchesanoInstitute of Applied Sciences and Intelligent Systems-Italian National Research Council (ISASI-CNR), Via Campi Flegrei 34, Pozzuoli, Napoli 80078, Italy.
Vito PagliaruloInstitute of Applied Sciences and Intelligent Systems-Italian National Research Council (ISASI-CNR), Via Campi Flegrei 34, Pozzuoli, Napoli 80078, Italy.
Federico OlivieriInstitute of Applied Sciences and Intelligent Systems-Italian National Research Council (ISASI-CNR), Via Campi Flegrei 34, Pozzuoli, Napoli 80078, Italy.
Sara CoppolaInstitute of Applied Sciences and Intelligent Systems-Italian National Research Council (ISASI-CNR), Via Campi Flegrei 34, Pozzuoli, Napoli 80078, Italy.
Melania PaturzoInstitute of Applied Sciences and Intelligent Systems-Italian National Research Council (ISASI-CNR), Via Campi Flegrei 34, Pozzuoli, Napoli 80078, Italy.
Pietro FerraroInstitute of Applied Sciences and Intelligent Systems-Italian National Research Council (ISASI-CNR), Via Campi Flegrei 34, Pozzuoli, Napoli 80078, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lab-on-a-Chip (LoC) devices are extremely promising in that they enable diagnostic functions at the point-of-care. Within this scope, an important goal is to design imaging schemes that can be used out of the laboratory. In this paper, we introduce and test a pocket holographic slide that allows digital holography microscopy to be performed without an interferometer setup. Instead, a commercial off-the-shelf plastic chip is engineered and functionalized with this aim. The microfluidic chip is endowed with micro-optics, that is, a diffraction grating and polymeric lenses, to build an interferometer directly on the chip, avoiding the need for a reference arm and external bulky optical components. Thanks to the single-beam scheme, the system is completely integrated and robust against vibrations, sharing the useful features of any common path interferometer. Hence, it becomes possible to bring holographic functionalities out of the lab, moving complexity from the external optical apparatus to the chip itself. Label-free imaging and quantitative phase contrast mapping of live samples are demonstrated, along with flexible refocusing capabilities. Thus, a liquid volume can be analyzed in one single shot with no need for mechanical scanning systems.

Indexed as

diffraction gratingsdigital holographyLab-on-a-Chipmicro-opticsoptical devicespolymer printing

Identifiers

PMID30167297
PMCPMC6062330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.